Published Data Registry

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Distinct steps of nuclear maturation of human pre-60S complexes require the activity of GTPases including GNL3L (Open Access) Thomé CC, Lemus-Diaz N, (...), Bohnsack KE Nucleic Acids Research 2026
Mechanism of human tRNA 3’CCA maturation (Open Access) Kuhle B, Krebs L, Bhatta A, Dennerlein S, Rehling P, Hillen HS bioRxiv 2026
CPF-CF-terminated snoRNAs shuttle through the cytoplasm via an mRNA guard protein-mediated surveillance mechanism (Open Access) Yu F, Zaccagnini G, (...), Krebber H Nature Communications 2026
Alphafold 3-guided insights into the Importinβ: Importin7 heterodimer interaction and its binding to histone H1 (Open Access) Neumann P, Dybkov O, Urlaub H, Ficner R, Dickmanns A Structure 2026
Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses (Open Access) Cui S, Batenburg NL, (...), Zhu X Cell Reports 2026
The E3-ome gene-centric compendium reveals the human E3 ligase landscape (Open Access) Chua NK, González-Robles TJ, (...), Feltham R Cell 2026
2′-O-methylation-dependent installation of N2-methylguanosine in the U6 internal stem loop facilitates efficient spliceosome assembly (Open Access) Kleiber N, Petrosyan J, (...), Bohnsack KE Nature Communications 2026
Molecular basis of human nuclear and mitochondrial tRNA 3′ processing (Open Access) Bhatta A, Kuhle B, (...), Hillen HS Nature Structural & Molecular Biology 2025
An avoidance segment resolves a lethal nuclear–mitochondrial targeting conflict during ribosome assembly Oborská-Oplová M, Geiger AG, (...), Panse VG Nature Cell Biology 2025
The plastid-encoded RNA polymerase of plant chloroplasts (Open Access) Ahrens FM, do Prado PF, Hillen HS, Pfannschmidt T Trends in Plant Science 2025
PLK1 inhibition delays mitotic entry revealing changes to the phosphoproteome of mammalian cells early in division (Open Access) Gobran M, Politi AZ, Welp L, Jakobi J, Urlaub H, Lenart P EMBO Journal 2025
Structural basis of Nipah virus RNA synthesis (Open Access) Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS Nature Communications 2025
Mechanisms of Enhancer-Mediated Gene Activation in the Context of the 3D Genome (Open Access) Papantonis A, Oudelaar AM Annual Review of Genomics and Human Genetics 2025
Author Correction: Structural basis of Nipah virus RNA synthesis (Open Access) Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS Nature Communications 2025
Coupling of ribosome biogenesis and translation initiation in human mitochondria (Open Access) Heinrichs M, Finke AF, (...), Richter-Dennerlein R Nature Communications 2025
Ribozyme‐catalyzed site‐specific labeling of RNA using O6‐alkylguanine SNAP‐tag substrates (Open Access) Walunj MB, Scheitl CP, Jungnickel T, Höbartner C Angewandte Chemie 2025
CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation (Open Access) Karpinska MA, Zhu Y, (...), Oudelaar AM Nature Structural & Molecular Biology 2025
Silencing mitochondrial gene expression in living cells Cruz-Zaragoza LD, Dahal D, (...), Rehling P Science 2025
The hidden power of antisense long non-coding RNAs: a dive into a novel regulatory layer mediated by double-stranded RNA formation (Open Access) Lamping J, Krebber H RNA Biology 2025
tRNA as an assembly chaperone for a macromolecular transcription-processing complex (Open Access) Bartuli J, Jungwirth S, (...), Fischer U Nature Structural & Molecular Biology 2025
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1 (Open Access) Orth B, Pohl P, (...), Lorenz S Nature Communications 2025
Manipulating mitochondrial gene expression (Open Access) Dahal D, Cruz-Zargoza LD, Rehling P Biological Chemistry 2025
Navigating Data Management Plans: From Terminological Confusion to Practical Implementation (Open Access) Ketabi A, Kossen R, (...), Krefting D German Medical Science GMS Publishing House 2025
FACT depletion demonstrates a role for nucleosome organization in TAD formation (Open Access) Mauksch C, Zhu Y, (...), Oudelaar AM Molecular Systems Biology 2025
Phosphoproteomic identification of Mos–MAPK targets in meiotic cell cycle and asymmetric oocyte divisions (Open Access) Avilov I, Horokhovskyi Y, (...), Lenart P Journal of Cell Biology 2025
Mechanisms and Determinants of −1 Ribosome Frameshifting and Bypassing Poulis P, Rodnina MV Cold Spring Harbor Perspectives in Biology 2025
FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites (Open Access) Antonicka H, Vučković A, (...), Shoubridge E Nucleic Acids Research 2025
Ca2+-Triggered (de)ubiquitination Events in Synapses (Open Access) Ainatzi S, Kaufmann SV, (...), Urlaub H Molecular & Cellular Proteomics 2025
Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates (Open Access) Walunj MB, Scheitl CPM, Jungnickel T, Höbartner C Angewandte Chemie-International Edition 2025
Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid–protein interaction sites by mass spectrometry (Open Access) Welp L, Wulf A, (...), Urlaub H Nucleic Acids Research 2025
Cotranslational protein folding through non-native structural intermediates (Open Access) Wang S, Bitran A, Samatova E, Shakhnovich EI, Rodnina MV Science Advances 2025
The functionality of telomerase depends on CPF–CF induced 3′end processing of its RNA component TLC1 and a novel Nrd1–Nab3 surveillance mechanism (Open Access) Lamping J, Krebber H Nucleic Acids Research 2025
Alphafold 3 guided insights into the Importin β - Importin 7 heterodimer interaction and its binding to Histone H1 (Open Access) Neumann P, Dybkov O, Urlaub H, Ficner R, Dickmanns A bioRxiv 2025
UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis (Open Access) Borisova E, Cuthill KJ, (...), Ambrozkiewicz MC bioRxiv 2025
NAC controls nascent chain fate through tunnel sensing and chaperone action (Open Access) Lee JH, Rabl L, (...), Frydman J bioRxiv 2025
The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses (Open Access) Cui S, Batenburg NL, (...), Zhu X bioRxiv 2025
NAC controls nascent chain fate through tunnel sensing and chaperone action (Open Access) Lee JH, Rabl L, (...), Frydman J Nature 2025
Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis (Open Access) Coßmann J, Kos PI, (...), Gebhardt JCM Nature Communications 2025
RNA polymerase II transcription compartments — from factories to condensates Rippe K, Papantonis A Nature Reviews Genetics 2025
Two distinct chromatin modules regulate proinflammatory gene expression Seufert I, Gerosa I, (...), Rippe K Nature Cell Biology 2025
Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides (Open Access) Ghosh Dastidar N, Freyer NS, (...), Wohlgemuth I Nature Communications 2025
RNA-modification by Base Exchange: Structure, Function and Application of tRNA-guanine Transglycosylases (Open Access) Reuter K, Ficner R Journal of Molecular Biology 2025
Structural and functional insights into tRNA recognition by human tRNA guanine transglycosylase Sievers K, Neumann P, (...), Ficner R Structure 2024
Rapid and synchronous chemical induction of replicative‐like senescence via a small molecule inhibitor (Open Access) Palikyras S, Sofiadis K, (...), Papantonis A Aging Cell 2024
In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization (Open Access) Oberbeckmann E, Quililan K, Cramer P, Oudelaar AM Nature Genetics 2024
Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile (Open Access) Filippopoulou C, Thomé CC, (...), Chachami G Cellular and Molecular Life Sciences 2024
Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair (Open Access) Kokic G, Yakoub G, (...), Luijsterburg MS Nature Structural & Molecular Biology 2024
Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1 (Open Access) Düring J, Wolter M, (...), Lorenz S Nature Structural & Molecular Biology 2024
RfaA (YqhY), a novel adaptor protein, controls metabolite-sensitive protein degradation in Bacillus subtilis (Open Access) Wicke D, Lentes S, (...), Stülke J bioRxiv 2024
Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins (Open Access) Zhang Z, Kumar V, (...), Lührmann R EMBO Journal 2024
Structure of the multi-subunit chloroplast RNA polymerase (Open Access) do Prado PF, Ahrens FM, (...), Hillen HS Molecular Cell 2024
Atomic Mutagenesis of N6-Methyladenosine Reveals Distinct Recognition Modes by Human m6A Reader and Eraser Proteins Seitz F, Jungnickel T, (...), Höbartner C Journal of the American Chemical Society 2024
Genome organization across scales: mechanistic insights from in vitro reconstitution studies (Open Access) Oberbeckmann E, Oudelaar AM Biochemical Society Transactions 2024
RfaA (YqhY), a novel adaptor protein, controls metabolite-sensitive protein degradation in Bacillus subtilis (Open Access) Wicke D, Lentes S, (...), Stülke J Researchsquare 2024
Structural basis of Integrator-dependent RNA polymerase II termination (Open Access) Fianu I, Ochmann M, (...), Cramer P Nature 2024
Molecular basis of human nuclear and mitochondrial tRNA 3'-processing (Open Access) Bhatta A, Kuhle B, (...), Hillen H bioRxiv 2024
How Natural Enzymes and Synthetic Ribozymes Generate Methylated Nucleotides in RNA Höbartner C, Bohnsack KE, Bohnsack MT Annual Review of Biochemistry 2024
Coenzyme A biosynthesis in Bacillus subtilis: Discovery of a novel precursor metabolite for salvage and its uptake system (Open Access) Warneke R, Herzberg C, (...), Stülke J bioRxiv 2024
Intensity and retention time prediction improves the rescoring of protein‐nucleic acid cross‐links (Open Access) Siraj A, Bouwmeester R, (...), Sachsenberg T Proteomics 2024
Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs (Open Access) Xie T, Danieli-Mackay A, (...), Papantonis A Nature Communications 2024
Kinetics of programmed and spontaneous ribosome sliding along the mRNA (Open Access) Senyushkina T, Samatova E, Klimova M, Rodnina M Nucleic Acids Research 2024
The molecular machinery for maturation of primary mtDNA transcripts (Open Access) Vučković A, Freyer C, Wredenberg A, Hillen HS Human Molecular Genetics 2024
Structural insights into the cross-exon to cross-intron spliceosome switch (Open Access) Zhang Z, Kumar V, (...), Lührmann R Nature 2024
Coordinating mitochondrial translation with assembly of the OXPHOS complexes (Open Access) Kremer LS, Rehling P Human Molecular Genetics 2024
dsRNA formation leads to preferential nuclear export and gene expression (Open Access) Coban I, Lamping J, (...), Krebber H Nature 2024
The maintenance of oocytes in the mammalian ovary involves extreme protein longevity (Open Access) Harasimov K, Gorry RL, (...), Schuh M Nature Cell Biology 2024
A roadmap for ribosome assembly in human mitochondria (Open Access) Lavdovskaia E, Hanitsch E, (...), Richter-Dennerlein R Nature Structural & Molecular Biology 2024
The relationship between nucleosome positioning and higher-order genome folding (Open Access) Aljahani A, Mauksch C, Oudelaar AM Current Opinion in Cell Biology 2024
Two distinct chromatin modules regulate proinflammatory gene expression (Open Access) Seufert I, Gerosa I, (...), Rippe K bioRxiv 2024
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites (Open Access) Antonicka H, Weraarpachai W, Vučković A, Hillen HS, Shoubridge EA bioRxiv 2024
Calcium-triggered (de)ubiquitination events in synapses (Open Access) Ainatzi S, Kaufmann SV, (...), Urlaub H bioRxiv 2024
Towards sustainable research data management of longitudinal, heterogeneous data from cardiac tissue engineering (Open Access) Smolorz SA, Dittrich GM, (...), Kusch H German Medical Science GMS Publishing House 2024
A new framework for SubtiWiki, the database for the model organism Bacillus subtilis (Open Access) Elfmann C, Dumann V, van den Berg T, Stülke J bioRxiv 2024
Kinetic mechanism and determinants of EF-P recruitment to translating ribosomes (Open Access) Mudryi V, Frister J, Peng B, Wohlgemuth I, Peske F, Rodnina M Nucleic Acids Research 2024
Structural basis of Nipah virus replication (Open Access) Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS bioRxiv 2024
A new framework for SubtiWiki, the database for the model organism Bacillus subtilis (Open Access) Elfmann C, Dumann V, van den Berg T, Stülke J Nucleic Acids Research 2024
Coenzyme A biosynthesis in Bacillus subtilis: discovery of a novel precursor metabolite for salvage and its uptake system (Open Access) Warneke R, Herzberg C, (...), Stülke J mBio 2024
Modelling protein complexes with crosslinking mass spectrometry and deep learning (Open Access) Stahl K, Warneke R, (...), Rappsilber J Nature Communications 2024
Phosphorylation of P-stalk proteins defines the ribosomal state for interaction with auxiliary protein factors (Open Access) Filipek K, Blanchet S, (...), Tchórzewski M EMBO Reports 2024
MDM4 exon skipping upon dysfunctional ribosome assembly (Open Access) Jansen J, Dobbelstein M Trends in Cell Biology 2024
CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation during cellular differentiation (Open Access) Karpinska MA, Zhu Y, (...), Oudelaar AM bioRxiv 2024
The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress (Open Access) Jansen J, Bohnsack KE, Böhlken-Fascher S, Bohnsack MT, Dobbelstein M Cell Reports 2024
Understanding ubiquitination in neurodevelopment by integrating insights across space and time Ambrozkiewicz MC, Lorenz S Nature Structural & Molecular Biology 2024
Defenders of the Transcriptome: Guard Protein-Mediated mRNA Quality Control in Saccharomyces cerevisiae (Open Access) Querl L, Krebber H International Journal of Molecular Sciences 2024
Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program (Open Access) Palikyras S, Varamogiani-Mamatsi V, (...), Papantonis A bioRxiv 2024
Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing (Open Access) Fendler NL, Ly J, (...), Vos SM Nucleic Acids Research 2024
Sophisticated natural products as antibiotics Lewis K, Lee RE, (...), Wohlgemuth I Nature 2024
N2-methylguanosine and N2, N2-dimethylguanosine in cytosolic and mitochondrial tRNAs (Open Access) Petrosyan J, Bohnsack KE Frontiers in RNA Research 2024
TOM-TIM23 supercomplex formation Jain N, Gomkale R, Rehling P Methods in Enzymology 2024
Age-associated changes in transcriptional elongation and their effects on homeostasis (Open Access) Papantonis A, Antebi A, Partridge L, Beyer A Trends in Cell Biology 2024
Translation factor accelerating peptide bond formation on the ribosome: EF-P and eIF5A as entropic catalysts and a potential drug targets (Open Access) Mudryi V, Peske F, Rodnina M BBA Advances 2023
Understudied Proteins and Understudied Functions in the Model Bacterium Bacillus subtilis - a Major Challenge in Current Research (Open Access) Stülke J, Wicke D, Meißner J, Warneke R, Elfmann C Authorea 2023
Understudied Proteins and Understudied Functions in the Model Bacterium Bacillus subtilis – a Major Challenge in Current Research (Open Access) Wicke D, Meißner J, Warneke R, Elfmann C, Stülke J Molecular Microbiology 2023
PAE Viewer: A webserver for the interactive visualization of the predicted aligned error for multimer structure predictions and crosslinks (Open Access) Elfmann C, Stülke J bioRxiv 2023
PAE viewer: a webserver for the interactive visualization of the predicted aligned error for multimer structure predictions and crosslinks (Open Access) Elfmann C, Stülke J Nucleic Acids Research 2023
Bacillus subtilis, a Swiss Army Knife in Science and Biotechnology Stülke J, Grüppen A, Bramkamp M, Pelzer S Journal of Bacteriology 2023
N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing (Open Access) Wang C, Ulryck N, (...), Graille M Nucleic Acids Research 2023
Ribozyme‐Catalyzed Late‐Stage Functionalization and Fluorogenic Labeling of RNA Scheitl CPM, Okuda T, Adelmann J, Höbartner C Angewandte Chemie 2023
Extreme structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs (Open Access) Xie T, Danieli-Mackay A, (...), Papantonis A bioRxiv 2023
Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile (Open Access) Filippopoulou C, Thome CC, (...), Chachami G bioRxiv 2023
Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex (Open Access) Jia J, Hilal T, (...), Wahl MC Nature Communications 2023
Human TRMT2A methylates tRNA and contributes to translation fidelity (Open Access) Witzenberger M, Burczyk S, (...), Niessing D Nucleic Acids Research 2023
The Mediator complex regulates enhancer-promoter interactions (Open Access) Ramasamy S, Aljahani A, (...), Oudelaar AM Nature Structural & Molecular Biology 2023
A viral ADP-ribosyltransferase attaches RNA chains to host proteins (Open Access) Wolfram-Schauerte M, Pozhydaieva N, (...), Höfer K Nature 2023
Cellular functions of eukaryotic RNA helicases and their links to human diseases Bohnsack KE, Yi S, Venus S, Jankowsky E, Bohnsack MT Nature Reviews Molecular Cell Biology 2023
Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm (Open Access) Grahn E, Kaufmann SV, (...), Kaupp U Nature Communications 2023
Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices (Open Access) Jentoft IM, Bäuerlein FJ, (...), Schuh M Cell 2023
Structure of the transcribing RNA polymerase II–Elongin complex (Open Access) Chen Y, Kokic G, Dienemann C, Dybkov O, Urlaub H, Cramer P Nature Structural & Molecular Biology 2023
Approaching automation of multiple instance orchestration of the menoci web portal (Open Access) Freckmann L, Henke C, (...), Kusch H Bausteine Forschungsdatenmanagement 2023
Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications Helm M, Bohnsack MT, (...), Stafforst T ACS Chemical Biology 2023
The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis in vitro (Open Access) Wicke D, Neumann P, (...), Stülke J Nucleic Acids Research 2023
Age-associated transcriptional stress due to accelerated elongation and increased stalling of RNAPII (Open Access) Papadakis A, Gyenis A, Pothof J, H. J. Hoeijmakers J, Papantonis A, Beyer A Nature Genetics 2023
Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis (Open Access) Dönig J, Mende H, (...), Müller S Nature Communications 2023
GPATCH4 regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and DHX15-independent manners (Open Access) Kanwal N, Krogh N, (...), Bohnsack M Nucleic Acids Research 2023
The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress (Open Access) Jansen J, Bohnsack KE, Böhlken-Fascher S, Bohnsack MT, Dobbelstein M bioRxiv 2023
The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis (Open Access) Wicke D, Neumann P, (...), Stülke J bioRxiv 2023
Ribozyme‐Catalyzed Late‐Stage Functionalization and Fluorogenic Labeling of RNA (Open Access) Scheitl CPM, Okuda T, Adelmann J, Höbartner C Angewandte Chemie-International Edition 2023
Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric oocyte divisions (Open Access) Avilov I, Horokhovskyi Y, (...), Lenart P bioRxiv 2023