| Distinct steps of nuclear maturation of human pre-60S complexes require the activity of GTPases including GNL3L |
|
Thomé CC, Lemus-Diaz N, (...), Bohnsack KE |
Nucleic Acids Research |
2026 |
|
|
| Mechanism of human tRNA 3’CCA maturation |
|
Kuhle B, Krebs L, Bhatta A, Dennerlein S, Rehling P, Hillen HS |
bioRxiv |
2026 |
|
|
| CPF-CF-terminated snoRNAs shuttle through the cytoplasm via an mRNA guard protein-mediated surveillance mechanism |
|
Yu F, Zaccagnini G, (...), Krebber H |
Nature Communications |
2026 |
|
|
| Alphafold 3-guided insights into the Importinβ: Importin7 heterodimer interaction and its binding to histone H1 |
|
Neumann P, Dybkov O, Urlaub H, Ficner R, Dickmanns A |
Structure |
2026 |
|
|
| Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses |
|
Cui S, Batenburg NL, (...), Zhu X |
Cell Reports |
2026 |
|
|
| The E3-ome gene-centric compendium reveals the human E3 ligase landscape |
|
Chua NK, González-Robles TJ, (...), Feltham R |
Cell |
2026 |
|
|
| 2′-O-methylation-dependent installation of N2-methylguanosine in the U6 internal stem loop facilitates efficient spliceosome assembly |
|
Kleiber N, Petrosyan J, (...), Bohnsack KE |
Nature Communications |
2026 |
|
|
| Molecular basis of human nuclear and mitochondrial tRNA 3′ processing |
|
Bhatta A, Kuhle B, (...), Hillen HS |
Nature Structural & Molecular Biology |
2025 |
|
|
| An avoidance segment resolves a lethal nuclear–mitochondrial targeting conflict during ribosome assembly |
|
Oborská-Oplová M, Geiger AG, (...), Panse VG |
Nature Cell Biology |
2025 |
|
|
| The plastid-encoded RNA polymerase of plant chloroplasts |
|
Ahrens FM, do Prado PF, Hillen HS, Pfannschmidt T |
Trends in Plant Science |
2025 |
|
|
| PLK1 inhibition delays mitotic entry revealing changes to the phosphoproteome of mammalian cells early in division |
|
Gobran M, Politi AZ, Welp L, Jakobi J, Urlaub H, Lenart P |
EMBO Journal |
2025 |
|
|
| Structural basis of Nipah virus RNA synthesis |
|
Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS |
Nature Communications |
2025 |
|
|
| Mechanisms of Enhancer-Mediated Gene Activation in the Context of the 3D Genome |
|
Papantonis A, Oudelaar AM |
Annual Review of Genomics and Human Genetics |
2025 |
|
|
| Author Correction: Structural basis of Nipah virus RNA synthesis |
|
Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS |
Nature Communications |
2025 |
|
|
| Coupling of ribosome biogenesis and translation initiation in human mitochondria |
|
Heinrichs M, Finke AF, (...), Richter-Dennerlein R |
Nature Communications |
2025 |
|
|
| Ribozyme‐catalyzed site‐specific labeling of RNA using O6‐alkylguanine SNAP‐tag substrates |
|
Walunj MB, Scheitl CP, Jungnickel T, Höbartner C |
Angewandte Chemie |
2025 |
|
|
| CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation |
|
Karpinska MA, Zhu Y, (...), Oudelaar AM |
Nature Structural & Molecular Biology |
2025 |
|
|
| Silencing mitochondrial gene expression in living cells |
|
Cruz-Zaragoza LD, Dahal D, (...), Rehling P |
Science |
2025 |
|
|
| The hidden power of antisense long non-coding RNAs: a dive into a novel regulatory layer mediated by double-stranded RNA formation |
|
Lamping J, Krebber H |
RNA Biology |
2025 |
|
|
| tRNA as an assembly chaperone for a macromolecular transcription-processing complex |
|
Bartuli J, Jungwirth S, (...), Fischer U |
Nature Structural & Molecular Biology |
2025 |
|
|
| Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1 |
|
Orth B, Pohl P, (...), Lorenz S |
Nature Communications |
2025 |
|
|
| Manipulating mitochondrial gene expression |
|
Dahal D, Cruz-Zargoza LD, Rehling P |
Biological Chemistry |
2025 |
|
|
| Navigating Data Management Plans: From Terminological Confusion to Practical Implementation |
|
Ketabi A, Kossen R, (...), Krefting D |
German Medical Science GMS Publishing House |
2025 |
|
|
| FACT depletion demonstrates a role for nucleosome organization in TAD formation |
|
Mauksch C, Zhu Y, (...), Oudelaar AM |
Molecular Systems Biology |
2025 |
|
|
| Phosphoproteomic identification of Mos–MAPK targets in meiotic cell cycle and asymmetric oocyte divisions |
|
Avilov I, Horokhovskyi Y, (...), Lenart P |
Journal of Cell Biology |
2025 |
|
|
| Mechanisms and Determinants of −1 Ribosome Frameshifting and Bypassing |
|
Poulis P, Rodnina MV |
Cold Spring Harbor Perspectives in Biology |
2025 |
|
|
| FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites |
|
Antonicka H, Vučković A, (...), Shoubridge E |
Nucleic Acids Research |
2025 |
|
|
| Ca2+-Triggered (de)ubiquitination Events in Synapses |
|
Ainatzi S, Kaufmann SV, (...), Urlaub H |
Molecular & Cellular Proteomics |
2025 |
|
|
| Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates |
|
Walunj MB, Scheitl CPM, Jungnickel T, Höbartner C |
Angewandte Chemie-International Edition |
2025 |
|
|
| Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid–protein interaction sites by mass spectrometry |
|
Welp L, Wulf A, (...), Urlaub H |
Nucleic Acids Research |
2025 |
|
|
| Cotranslational protein folding through non-native structural intermediates |
|
Wang S, Bitran A, Samatova E, Shakhnovich EI, Rodnina MV |
Science Advances |
2025 |
|
|
| The functionality of telomerase depends on CPF–CF induced 3′end processing of its RNA component TLC1 and a novel Nrd1–Nab3 surveillance mechanism |
|
Lamping J, Krebber H |
Nucleic Acids Research |
2025 |
|
|
| Alphafold 3 guided insights into the Importin β - Importin 7 heterodimer interaction and its binding to Histone H1 |
|
Neumann P, Dybkov O, Urlaub H, Ficner R, Dickmanns A |
bioRxiv |
2025 |
|
|
| UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis |
|
Borisova E, Cuthill KJ, (...), Ambrozkiewicz MC |
bioRxiv |
2025 |
|
|
| NAC controls nascent chain fate through tunnel sensing and chaperone action |
|
Lee JH, Rabl L, (...), Frydman J |
bioRxiv |
2025 |
|
|
| The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses |
|
Cui S, Batenburg NL, (...), Zhu X |
bioRxiv |
2025 |
|
|
| NAC controls nascent chain fate through tunnel sensing and chaperone action |
|
Lee JH, Rabl L, (...), Frydman J |
Nature |
2025 |
|
|
| Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis |
|
Coßmann J, Kos PI, (...), Gebhardt JCM |
Nature Communications |
2025 |
|
|
| RNA polymerase II transcription compartments — from factories to condensates |
|
Rippe K, Papantonis A |
Nature Reviews Genetics |
2025 |
|
|
| Two distinct chromatin modules regulate proinflammatory gene expression |
|
Seufert I, Gerosa I, (...), Rippe K |
Nature Cell Biology |
2025 |
|
|
| Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides |
|
Ghosh Dastidar N, Freyer NS, (...), Wohlgemuth I |
Nature Communications |
2025 |
|
|
| RNA-modification by Base Exchange: Structure, Function and Application of tRNA-guanine Transglycosylases |
|
Reuter K, Ficner R |
Journal of Molecular Biology |
2025 |
|
|
| Structural and functional insights into tRNA recognition by human tRNA guanine transglycosylase |
|
Sievers K, Neumann P, (...), Ficner R |
Structure |
2024 |
|
|
| Rapid and synchronous chemical induction of replicative‐like senescence via a small molecule inhibitor |
|
Palikyras S, Sofiadis K, (...), Papantonis A |
Aging Cell |
2024 |
|
|
| In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization |
|
Oberbeckmann E, Quililan K, Cramer P, Oudelaar AM |
Nature Genetics |
2024 |
|
|
| Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile |
|
Filippopoulou C, Thomé CC, (...), Chachami G |
Cellular and Molecular Life Sciences |
2024 |
|
|
| Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair |
|
Kokic G, Yakoub G, (...), Luijsterburg MS |
Nature Structural & Molecular Biology |
2024 |
|
|
| Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1 |
|
Düring J, Wolter M, (...), Lorenz S |
Nature Structural & Molecular Biology |
2024 |
|
|
| RfaA (YqhY), a novel adaptor protein, controls metabolite-sensitive protein degradation in Bacillus subtilis |
|
Wicke D, Lentes S, (...), Stülke J |
bioRxiv |
2024 |
|
|
| Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins |
|
Zhang Z, Kumar V, (...), Lührmann R |
EMBO Journal |
2024 |
|
|
| Structure of the multi-subunit chloroplast RNA polymerase |
|
do Prado PF, Ahrens FM, (...), Hillen HS |
Molecular Cell |
2024 |
|
|
| Atomic Mutagenesis of N6-Methyladenosine Reveals Distinct Recognition Modes by Human m6A Reader and Eraser Proteins |
|
Seitz F, Jungnickel T, (...), Höbartner C |
Journal of the American Chemical Society |
2024 |
|
|
| Genome organization across scales: mechanistic insights from in vitro reconstitution studies |
|
Oberbeckmann E, Oudelaar AM |
Biochemical Society Transactions |
2024 |
|
|
| RfaA (YqhY), a novel adaptor protein, controls metabolite-sensitive protein degradation in Bacillus subtilis |
|
Wicke D, Lentes S, (...), Stülke J |
Researchsquare |
2024 |
|
|
| Structural basis of Integrator-dependent RNA polymerase II termination |
|
Fianu I, Ochmann M, (...), Cramer P |
Nature |
2024 |
|
|
| Molecular basis of human nuclear and mitochondrial tRNA 3'-processing |
|
Bhatta A, Kuhle B, (...), Hillen H |
bioRxiv |
2024 |
|
|
| How Natural Enzymes and Synthetic Ribozymes Generate Methylated Nucleotides in RNA |
|
Höbartner C, Bohnsack KE, Bohnsack MT |
Annual Review of Biochemistry |
2024 |
|
|
| Coenzyme A biosynthesis in Bacillus subtilis: Discovery of a novel precursor metabolite for salvage and its uptake system |
|
Warneke R, Herzberg C, (...), Stülke J |
bioRxiv |
2024 |
|
|
| Intensity and retention time prediction improves the rescoring of protein‐nucleic acid cross‐links |
|
Siraj A, Bouwmeester R, (...), Sachsenberg T |
Proteomics |
2024 |
|
|
| Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs |
|
Xie T, Danieli-Mackay A, (...), Papantonis A |
Nature Communications |
2024 |
|
|
| Kinetics of programmed and spontaneous ribosome sliding along the mRNA |
|
Senyushkina T, Samatova E, Klimova M, Rodnina M |
Nucleic Acids Research |
2024 |
|
|
| The molecular machinery for maturation of primary mtDNA transcripts |
|
Vučković A, Freyer C, Wredenberg A, Hillen HS |
Human Molecular Genetics |
2024 |
|
|
| Structural insights into the cross-exon to cross-intron spliceosome switch |
|
Zhang Z, Kumar V, (...), Lührmann R |
Nature |
2024 |
|
|
| Coordinating mitochondrial translation with assembly of the OXPHOS complexes |
|
Kremer LS, Rehling P |
Human Molecular Genetics |
2024 |
|
|
| dsRNA formation leads to preferential nuclear export and gene expression |
|
Coban I, Lamping J, (...), Krebber H |
Nature |
2024 |
|
|
| The maintenance of oocytes in the mammalian ovary involves extreme protein longevity |
|
Harasimov K, Gorry RL, (...), Schuh M |
Nature Cell Biology |
2024 |
|
|
| A roadmap for ribosome assembly in human mitochondria |
|
Lavdovskaia E, Hanitsch E, (...), Richter-Dennerlein R |
Nature Structural & Molecular Biology |
2024 |
|
|
| The relationship between nucleosome positioning and higher-order genome folding |
|
Aljahani A, Mauksch C, Oudelaar AM |
Current Opinion in Cell Biology |
2024 |
|
|
| Two distinct chromatin modules regulate proinflammatory gene expression |
|
Seufert I, Gerosa I, (...), Rippe K |
bioRxiv |
2024 |
|
|
| FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites |
|
Antonicka H, Weraarpachai W, Vučković A, Hillen HS, Shoubridge EA |
bioRxiv |
2024 |
|
|
| Calcium-triggered (de)ubiquitination events in synapses |
|
Ainatzi S, Kaufmann SV, (...), Urlaub H |
bioRxiv |
2024 |
|
|
| Towards sustainable research data management of longitudinal, heterogeneous data from cardiac tissue engineering |
|
Smolorz SA, Dittrich GM, (...), Kusch H |
German Medical Science GMS Publishing House |
2024 |
|
|
| A new framework for SubtiWiki, the database for the model organism Bacillus subtilis |
|
Elfmann C, Dumann V, van den Berg T, Stülke J |
bioRxiv |
2024 |
|
|
| Kinetic mechanism and determinants of EF-P recruitment to translating ribosomes |
|
Mudryi V, Frister J, Peng B, Wohlgemuth I, Peske F, Rodnina M |
Nucleic Acids Research |
2024 |
|
|
| Structural basis of Nipah virus replication |
|
Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS |
bioRxiv |
2024 |
|
|
| A new framework for SubtiWiki, the database for the model organism Bacillus subtilis |
|
Elfmann C, Dumann V, van den Berg T, Stülke J |
Nucleic Acids Research |
2024 |
|
|
| Coenzyme A biosynthesis in Bacillus subtilis: discovery of a novel precursor metabolite for salvage and its uptake system |
|
Warneke R, Herzberg C, (...), Stülke J |
mBio |
2024 |
|
|
| Modelling protein complexes with crosslinking mass spectrometry and deep learning |
|
Stahl K, Warneke R, (...), Rappsilber J |
Nature Communications |
2024 |
|
|
| Phosphorylation of P-stalk proteins defines the ribosomal state for interaction with auxiliary protein factors |
|
Filipek K, Blanchet S, (...), Tchórzewski M |
EMBO Reports |
2024 |
|
|
| MDM4 exon skipping upon dysfunctional ribosome assembly |
|
Jansen J, Dobbelstein M |
Trends in Cell Biology |
2024 |
|
|
| CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation during cellular differentiation |
|
Karpinska MA, Zhu Y, (...), Oudelaar AM |
bioRxiv |
2024 |
|
|
| The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress |
|
Jansen J, Bohnsack KE, Böhlken-Fascher S, Bohnsack MT, Dobbelstein M |
Cell Reports |
2024 |
|
|
| Understanding ubiquitination in neurodevelopment by integrating insights across space and time |
|
Ambrozkiewicz MC, Lorenz S |
Nature Structural & Molecular Biology |
2024 |
|
|
| Defenders of the Transcriptome: Guard Protein-Mediated mRNA Quality Control in Saccharomyces cerevisiae |
|
Querl L, Krebber H |
International Journal of Molecular Sciences |
2024 |
|
|
| Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program |
|
Palikyras S, Varamogiani-Mamatsi V, (...), Papantonis A |
bioRxiv |
2024 |
|
|
| Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing |
|
Fendler NL, Ly J, (...), Vos SM |
Nucleic Acids Research |
2024 |
|
|
| Sophisticated natural products as antibiotics |
|
Lewis K, Lee RE, (...), Wohlgemuth I |
Nature |
2024 |
|
|
| N2-methylguanosine and N2, N2-dimethylguanosine in cytosolic and mitochondrial tRNAs |
|
Petrosyan J, Bohnsack KE |
Frontiers in RNA Research |
2024 |
|
|
| TOM-TIM23 supercomplex formation |
|
Jain N, Gomkale R, Rehling P |
Methods in Enzymology |
2024 |
|
|
| Age-associated changes in transcriptional elongation and their effects on homeostasis |
|
Papantonis A, Antebi A, Partridge L, Beyer A |
Trends in Cell Biology |
2024 |
|
|
| Translation factor accelerating peptide bond formation on the ribosome: EF-P and eIF5A as entropic catalysts and a potential drug targets |
|
Mudryi V, Peske F, Rodnina M |
BBA Advances |
2023 |
|
|
| Understudied Proteins and Understudied Functions in the Model Bacterium Bacillus subtilis - a Major Challenge in Current Research |
|
Stülke J, Wicke D, Meißner J, Warneke R, Elfmann C |
Authorea |
2023 |
|
|
| Understudied Proteins and Understudied Functions in the Model Bacterium Bacillus subtilis – a Major Challenge in Current Research |
|
Wicke D, Meißner J, Warneke R, Elfmann C, Stülke J |
Molecular Microbiology |
2023 |
|
|
| PAE Viewer: A webserver for the interactive visualization of the predicted aligned error for multimer structure predictions and crosslinks |
|
Elfmann C, Stülke J |
bioRxiv |
2023 |
|
|
| PAE viewer: a webserver for the interactive visualization of the predicted aligned error for multimer structure predictions and crosslinks |
|
Elfmann C, Stülke J |
Nucleic Acids Research |
2023 |
|
|
| Bacillus subtilis, a Swiss Army Knife in Science and Biotechnology |
|
Stülke J, Grüppen A, Bramkamp M, Pelzer S |
Journal of Bacteriology |
2023 |
|
|
| N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing |
|
Wang C, Ulryck N, (...), Graille M |
Nucleic Acids Research |
2023 |
|
|
| Ribozyme‐Catalyzed Late‐Stage Functionalization and Fluorogenic Labeling of RNA |
|
Scheitl CPM, Okuda T, Adelmann J, Höbartner C |
Angewandte Chemie |
2023 |
|
|
| Extreme structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs |
|
Xie T, Danieli-Mackay A, (...), Papantonis A |
bioRxiv |
2023 |
|
|
| Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile |
|
Filippopoulou C, Thome CC, (...), Chachami G |
bioRxiv |
2023 |
|
|
| Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex |
|
Jia J, Hilal T, (...), Wahl MC |
Nature Communications |
2023 |
|
|
| Human TRMT2A methylates tRNA and contributes to translation fidelity |
|
Witzenberger M, Burczyk S, (...), Niessing D |
Nucleic Acids Research |
2023 |
|
|
| The Mediator complex regulates enhancer-promoter interactions |
|
Ramasamy S, Aljahani A, (...), Oudelaar AM |
Nature Structural & Molecular Biology |
2023 |
|
|
| A viral ADP-ribosyltransferase attaches RNA chains to host proteins |
|
Wolfram-Schauerte M, Pozhydaieva N, (...), Höfer K |
Nature |
2023 |
|
|
| Cellular functions of eukaryotic RNA helicases and their links to human diseases |
|
Bohnsack KE, Yi S, Venus S, Jankowsky E, Bohnsack MT |
Nature Reviews Molecular Cell Biology |
2023 |
|
|
| Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm |
|
Grahn E, Kaufmann SV, (...), Kaupp U |
Nature Communications |
2023 |
|
|
| Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices |
|
Jentoft IM, Bäuerlein FJ, (...), Schuh M |
Cell |
2023 |
|
|
| Structure of the transcribing RNA polymerase II–Elongin complex |
|
Chen Y, Kokic G, Dienemann C, Dybkov O, Urlaub H, Cramer P |
Nature Structural & Molecular Biology |
2023 |
|
|
| Approaching automation of multiple instance orchestration of the menoci web portal |
|
Freckmann L, Henke C, (...), Kusch H |
Bausteine Forschungsdatenmanagement |
2023 |
|
|
| Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications |
|
Helm M, Bohnsack MT, (...), Stafforst T |
ACS Chemical Biology |
2023 |
|
|
| The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis in vitro |
|
Wicke D, Neumann P, (...), Stülke J |
Nucleic Acids Research |
2023 |
|
|
| Age-associated transcriptional stress due to accelerated elongation and increased stalling of RNAPII |
|
Papadakis A, Gyenis A, Pothof J, H. J. Hoeijmakers J, Papantonis A, Beyer A |
Nature Genetics |
2023 |
|
|
| Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis |
|
Dönig J, Mende H, (...), Müller S |
Nature Communications |
2023 |
|
|
| GPATCH4 regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and DHX15-independent manners |
|
Kanwal N, Krogh N, (...), Bohnsack M |
Nucleic Acids Research |
2023 |
|
|
| The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress |
|
Jansen J, Bohnsack KE, Böhlken-Fascher S, Bohnsack MT, Dobbelstein M |
bioRxiv |
2023 |
|
|
| The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis |
|
Wicke D, Neumann P, (...), Stülke J |
bioRxiv |
2023 |
|
|
| Ribozyme‐Catalyzed Late‐Stage Functionalization and Fluorogenic Labeling of RNA |
|
Scheitl CPM, Okuda T, Adelmann J, Höbartner C |
Angewandte Chemie-International Edition |
2023 |
|
|
| Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric oocyte divisions |
|
Avilov I, Horokhovskyi Y, (...), Lenart P |
bioRxiv |
2023 |
|
|