| Property |
Value |
| Working Groups |
RG Lenz, 
RG Lorenz, 
RG Papantonis, 
RG Urlaub |
| Subproject |
P17 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
40897715 |
| DOI |
10.1038/s41467-025-63442-x |
| Publication Year |
2025 |
| Title |
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1 |
| Journal |
Nature Communications |
| ISSN |
2041-1723 |
| eISSN |
2041-1723 |
| URL |
https://doi.org/10.1038/s41467-025-63442-x |
| Issue |
1 |
| Volume |
16 |
| Journal Abbreviation |
Nat Commun |
| Authors |
Orth B, Pohl P, Aust F, Ji Y, Seenivasan A, Dybkov O, Liang XJ, Bock L, Leidner F, Levantovsky S, Schardey P, Sander P, Disch NJ, Trautz ML, Mizi A, Papantonis A, Lenz C, Grubmüller H, Steinchen W, Behrends C, Urlaub H, Gehringer M, Lorenz S |
| First Author |
Orth B |
| Last Author |
Lorenz S |
External Resources
42230https://www.addgene.org/42230 Addgene identifier (42230, reused)
48138https://www.addgene.org/48138 Addgene identifier (48138, reused)
61585https://www.addgene.org/61585 Addgene identifier (61585, reused)
187142https://www.addgene.org/187142 Addgene identifier (187142, reused)
nature.c...-x.pdfhttps://www.nature.com/articles/s41467-025-63442-x.pdf Article fulltext
gro-217702http://resolver.sub.uni-goettingen.de/purl?gro-217702 GRO.publications identifier
0000-0003-1577-7309https://orcid.org/0000-0003-1577-7309 ORCID identifier (Pavel Pohl)
0009-0002-2021-7146https://orcid.org/0009-0002-2021-7146 ORCID identifier (Florian Aust)
0000-0002-9741-5119https://orcid.org/0000-0002-9741-5119 ORCID identifier (Yanlong Ji)
0000-0002-4340-5847https://orcid.org/0000-0002-4340-5847 ORCID identifier (Ayshwarya Seenivasan)
0000-0001-6005-7242https://orcid.org/0000-0001-6005-7242 ORCID identifier (Olexandr Dybkov)
0000-0003-4554-7336https://orcid.org/0000-0003-4554-7336 ORCID identifier (Lars V. Bock)
0000-0002-0048-889Xhttps://orcid.org/0000-0002-0048-889X ORCID identifier (Florian Leidner)
0000-0002-0918-6871https://orcid.org/0000-0002-0918-6871 ORCID identifier (Sophie Levantovsky)
0009-0004-0410-1199https://orcid.org/0009-0004-0410-1199 ORCID identifier (Pascal Sander)
0000-0002-4313-491Xhttps://orcid.org/0000-0002-4313-491X ORCID identifier (Athanasia Mizi)
0000-0001-7551-1073https://orcid.org/0000-0001-7551-1073 ORCID identifier (Argyris Papantonis)
0000-0002-0946-8166https://orcid.org/0000-0002-0946-8166 ORCID identifier (Christof Lenz)
0000-0002-3270-3144https://orcid.org/0000-0002-3270-3144 ORCID identifier (Helmut Grubmüller)
0000-0003-2990-3660https://orcid.org/0000-0003-2990-3660 ORCID identifier (Wieland Steinchen)
0000-0002-9184-7607https://orcid.org/0000-0002-9184-7607 ORCID identifier (Christian Behrends)
0000-0003-1837-5233https://orcid.org/0000-0003-1837-5233 ORCID identifier (Henning Urlaub)
0000-0002-9639-2381https://orcid.org/0000-0002-9639-2381 ORCID identifier (Sonja Gisela Lorenz)
PXD063550http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD063550 Pride proteome dataset (PXD063550)
PXD066563http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD066563 Pride proteome dataset (PXD066563)
PXD067088http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD067088 Pride proteome dataset (PXD067088)
398https://sfb1286.uni-goettingen.de/literature/publications/398 Published Data Registry entry (CRC 1286)
6XZ1https://www.rcsb.org/structure/6XZ1 RCSB PDB Identifier (DOI:10.2210/pdb6XZ1/pdb, reused)
5/24https://rdp.sfb1565.uni-goettingen.de/archive/5/24 Research Data Archive (supplemental material)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
025z3z560https://ror.org/025z3z560 ROR identifier (025z3z560, Munich Cluster for Systems Neurology)
01rdrb571https://ror.org/01rdrb571 ROR identifier (01rdrb571, Philipps University of Marburg)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
03a1kwz48https://ror.org/03a1kwz48 ROR identifier (03a1kwz48, University of Tübingen)
CVCL_0063https://scicrunch.org/resolver/CVCL_0063 SciCrunch identifier (RRID:CVCL_0063, HEK293T)
SCR_025454https://scicrunch.org/resolver/SCR_025454 SciCrunch identifier (RRID:SCR_025454, AlphaFold)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_014565https://scicrunch.org/resolver/SCR_014565 SciCrunch identifier (RRID:SCR_014565, GROMACS)
SCR_013715https://scicrunch.org/resolver/SCR_013715 SciCrunch identifier (RRID:SCR_013715, Image Studio Lite)
SCR_013673https://scicrunch.org/resolver/SCR_013673 SciCrunch identifier (RRID:SCR_013673, Leica Application Suite X)
SCR_014485https://scicrunch.org/resolver/SCR_014485 SciCrunch identifier (RRID:SCR_014485, MaxQuant)
SCR_014212https://scicrunch.org/resolver/SCR_014212 SciCrunch identifier (RRID:SCR_014212, Origin)
SCR_015753https://scicrunch.org/resolver/SCR_015753 SciCrunch identifier (RRID:SCR_015753, Perseus)
SCR_016664https://scicrunch.org/resolver/SCR_016664 SciCrunch identifier (RRID:SCR_016664, ProteinLynx Global Server)
SCR_000305https://scicrunch.org/resolver/SCR_000305 SciCrunch identifier (RRID:SCR_000305, PyMOL)
SCR_008394https://scicrunch.org/resolver/SCR_008394 SciCrunch identifier (RRID:SCR_008394, Python)
SCR_014593https://scicrunch.org/resolver/SCR_014593 SciCrunch identifier (RRID:SCR_014593, Thermo Xcalibur)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-63442-x/MediaObjects/41467_2025_63442_MOESM1_ESM.pdf Supplemental material
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-63442-x/MediaObjects/41467_2025_63442_MOESM2_ESM.pdf Supplemental material
goeseek.gwdguser.de/studies/247https://goeseek.gwdguser.de/studies/247 Supplemental material (goeseek study)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-63442-x/MediaObjects/41467_2025_63442_MOESM6_ESM.pdf Supplemental material (peer review)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-63442-x/MediaObjects/41467_2025_63442_MOESM5_ESM.pdf Supplemental material (reporting summary)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-63442-x/MediaObjects/41467_2025_63442_MOESM7_ESM.xlsx Supplemental material (source data)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-63442-x/MediaObjects/41467_2025_63442_MOESM3_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-63442-x/MediaObjects/41467_2025_63442_MOESM4_ESM.xlsx Supplemental material (table)
10.5281/zenodo.15772692https://doi.org/10.5281/zenodo.15772692 Zenodo identifier (10.5281/zenodo.15772692)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0132 |
|
primary |
|
AB_2940834 |
PTMScan® Ubiquitin Remnant Motif (K-ε-GG) Kit |
| primary-0163 |
|
primary |
ACTB |
AB_476692 |
Anti-β-Actin antibody |
| primary-0164 |
|
primary |
HUWE1 |
AB_10922588 |
HECTH9 (AX8D1) Mouse mAb |
| primary-0165 |
|
primary |
MCL1 |
AB_2722740 |
Mcl-1 (D2W9E) Rabbit mAb |
| primary-0166 |
|
primary |
HA |
AB_439705 |
Monoklonaler ANTI-HA-Antikörper |
| secondary-0167 |
|
secondary |
|
AB_2099233 |
Anti-rabbit IgG, HRP-linked Antibody |
| secondary-0168 |
|
secondary |
|
AB_330924 |
Anti-mouse IgG, HRP-linked Antibody |