| Property |
Value |
| Working Groups |
RG Lorenz |
| Subproject |
P17 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
41864206 |
| DOI |
10.1016/j.cell.2026.01.029 |
| Publication Year |
2026 |
| Title |
The E3-ome gene-centric compendium reveals the human E3 ligase landscape |
| Journal |
Cell |
| ISSN |
0092-8674 |
| eISSN |
1097-4172 |
| URL |
https://doi.org/10.1016/j.cell.2026.01.029 |
| Journal Abbreviation |
Cell |
| Authors |
Chua NK, González-Robles TJ, Reddington CJ, Dudley-Fraser J, Birkinshaw RW, Han J, Solano A, Wong SW, Kochańczyk T, Peter JJ, Nakasone MA, Aust F, Munro J, Tong YH, Iskander J, Abeysekera W, Garnham A, Huckstep H, Ritchie ME, Wertz I, Hymowitz S, Kumar S, Conaway RC, Privé GG, Bullock AN, Babon JJ, Klevit RE, Lorenz S, Ciulli A, Fischer ES, Thomä NH, Nowak RP, Schulman BA, Rapé M, Rittinger K, Pagan JK, Bahlo M, Mackay JP, Mace PD, Lima CD, Hay RT, Komander D, Lechtenberg BC, Joazeiro CA, Pagano M, Hofmann K, Feltham R |
| First Author |
Chua NK |
| Last Author |
Feltham R |
External Resources
41142https://www.addgene.org/41142 Addgene identifier (41142, reused)
41143https://www.addgene.org/41143 Addgene identifier (41143, reused)
scienced...in.pdfhttps://www.sciencedirect.com/science/article/pii/S0092867426001169/pdfft?md5=0273370c7d98b698d4051889b2126263&pid=1-s2.0-S0092867426001169-main.pdf Article fulltext
0000-0001-9292-382Xhttps://orcid.org/0000-0001-9292-382X ORCID identifier (Tania J. González-Robles)
0000-0003-0412-8039https://orcid.org/0000-0003-0412-8039 ORCID identifier (Cameron J. Reddington)
0000-0003-1571-3524https://orcid.org/0000-0003-1571-3524 ORCID identifier (Jane Dudley-Fraser)
0000-0003-1825-0182https://orcid.org/0000-0003-1825-0182 ORCID identifier (Richard W. Birkinshaw)
0009-0008-0865-8874https://orcid.org/0009-0008-0865-8874 ORCID identifier (Ashleigh Solano)
0000-0002-7994-1836https://orcid.org/0000-0002-7994-1836 ORCID identifier (Soon Wie Wong)
0000-0002-4989-8064https://orcid.org/0000-0002-4989-8064 ORCID identifier (Tomasz Kochańczyk)
0000-0002-1362-191Xhttps://orcid.org/0000-0002-1362-191X ORCID identifier (Mark A. Nakasone)
0009-0002-2021-7146https://orcid.org/0009-0002-2021-7146 ORCID identifier (Florian Aust)
0000-0002-2751-0989https://orcid.org/0000-0002-2751-0989 ORCID identifier (Jacob Munro)
0009-0008-1397-6519https://orcid.org/0009-0008-1397-6519 ORCID identifier (Yeh Huei Tong)
0000-0002-3426-4376https://orcid.org/0000-0002-3426-4376 ORCID identifier (Julie Iskander)
0000-0002-3110-8984https://orcid.org/0000-0002-3110-8984 ORCID identifier (Waruni Abeysekera)
000-0001-5451-294Xhttps://orcid.org/000-0001-5451-294X ORCID identifier (Hannah Huckstep)
0000-0002-7383-0609https://orcid.org/0000-0002-7383-0609 ORCID identifier (Matthew E. Ritchie)
0000-0002-7979-9374https://orcid.org/0000-0002-7979-9374 ORCID identifier (Ingrid Wertz)
0000-0003-4743-4386https://orcid.org/0000-0003-4743-4386 ORCID identifier (Sarah G. Hymowitz)
0000-0001-7126-9814https://orcid.org/0000-0001-7126-9814 ORCID identifier (Sharad Kumar)
0000-0002-0712-4319https://orcid.org/0000-0002-0712-4319 ORCID identifier (Gilbert G. Privé)
0000-0001-6757-0436https://orcid.org/0000-0001-6757-0436 ORCID identifier (Alex N. Bullock)
0000-0002-5408-6239https://orcid.org/0000-0002-5408-6239 ORCID identifier (Jeffrey J. Babon)
0000-0002-3476-969Xhttps://orcid.org/0000-0002-3476-969X ORCID identifier (Rachel E. Klevit)
0000-0002-9639-2381https://orcid.org/0000-0002-9639-2381 ORCID identifier (Sonja Gisela Lorenz)
0000-0002-8654-1670https://orcid.org/0000-0002-8654-1670 ORCID identifier (Alessio Ciulli)
0000-0001-7337-6306https://orcid.org/0000-0001-7337-6306 ORCID identifier (Eric S. Fischer)
0000-0003-2685-906Xhttps://orcid.org/0000-0003-2685-906X ORCID identifier (Nicolas H. Thomä)
0000-0002-0605-0071https://orcid.org/0000-0002-0605-0071 ORCID identifier (Radosław P. Nowak)
0000-0002-3083-1126https://orcid.org/0000-0002-3083-1126 ORCID identifier (Brenda A. Schulman)
0000-0003-4849-6343https://orcid.org/0000-0003-4849-6343 ORCID identifier (Michael Rapé)
0000-0002-7698-4435https://orcid.org/0000-0002-7698-4435 ORCID identifier (Katrin Rittinger)
0000-0002-7079-6388https://orcid.org/0000-0002-7079-6388 ORCID identifier (Julia K. Pagan)
0000-0001-5132-0774https://orcid.org/0000-0001-5132-0774 ORCID identifier (Melanie Bahlo)
0000-0001-7508-8033https://orcid.org/0000-0001-7508-8033 ORCID identifier (Joel P. Mackay)
0000-0003-2175-9537https://orcid.org/0000-0003-2175-9537 ORCID identifier (Peter D. Mace)
0000-0002-9163-6092https://orcid.org/0000-0002-9163-6092 ORCID identifier (Christopher D. Lima)
0000-0001-7113-9024https://orcid.org/0000-0001-7113-9024 ORCID identifier (Ronald T. Hay)
0000-0002-8092-4320https://orcid.org/0000-0002-8092-4320 ORCID identifier (David Komander)
0000-0002-5674-6894https://orcid.org/0000-0002-5674-6894 ORCID identifier (Bernhard C. Lechtenberg)
0000-0003-1433-8013https://orcid.org/0000-0003-1433-8013 ORCID identifier (Claudio A.P. Joazeiro)
0000-0003-3210-2442https://orcid.org/0000-0003-3210-2442 ORCID identifier (Michele Pagano)
0000-0002-2289-9083https://orcid.org/0000-0002-2289-9083 ORCID identifier (Kay Hofmann)
0000-0001-8376-6869https://orcid.org/0000-0001-8376-6869 ORCID identifier (Rebecca Feltham)
028g18b61https://ror.org/028g18b61 ROR identifier (028g18b61, Adelaide University)
02jzgtq86https://ror.org/02jzgtq86 ROR identifier (02jzgtq86, Dana-Farber Cancer Institute)
02s376052https://ror.org/02s376052 ROR identifier (02s376052, École Polytechnique Fédérale de Lausanne)
01kpzv902https://ror.org/01kpzv902 ROR identifier (01kpzv902, Flinders University)
04cdgtt98https://ror.org/04cdgtt98 ROR identifier (04cdgtt98, German Cancer Research Center)
03vek6s52https://ror.org/03vek6s52 ROR identifier (03vek6s52, Harvard University)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
04py35477https://ror.org/04py35477 ROR identifier (04py35477, Max Planck Institute of Biochemistry)
02yrq0923https://ror.org/02yrq0923 ROR identifier (02yrq0923, Memorial Sloan Kettering Cancer Center)
0190ak572https://ror.org/0190ak572 ROR identifier (0190ak572, New York University)
03zayce58https://ror.org/03zayce58 ROR identifier (03zayce58, Princess Margaret Cancer Centre)
04tnbqb63https://ror.org/04tnbqb63 ROR identifier (04tnbqb63, The Francis Crick Institute)
056pdzs28https://ror.org/056pdzs28 ROR identifier (056pdzs28, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology)
05byvp690https://ror.org/05byvp690 ROR identifier (05byvp690, The University of Texas Southwestern Medical Center)
041nas322https://ror.org/041nas322 ROR identifier (041nas322, University of Bonn)
01an7q238https://ror.org/01an7q238 ROR identifier (01an7q238, University of California, Berkeley)
00rcxh774https://ror.org/00rcxh774 ROR identifier (00rcxh774, University of Cologne)
03h2bxq36https://ror.org/03h2bxq36 ROR identifier (03h2bxq36, University of Dundee)
01ej9dk98https://ror.org/01ej9dk98 ROR identifier (01ej9dk98, University of Melbourne)
01jmxt844https://ror.org/01jmxt844 ROR identifier (01jmxt844, University of Otago)
052gg0110https://ror.org/052gg0110 ROR identifier (052gg0110, University of Oxford)
00rqy9422https://ror.org/00rqy9422 ROR identifier (00rqy9422, University of Queensland)
01p93h210https://ror.org/01p93h210 ROR identifier (01p93h210, University of South Australia)
0384j8v12https://ror.org/0384j8v12 ROR identifier (0384j8v12, University of Sydney)
03dbr7087https://ror.org/03dbr7087 ROR identifier (03dbr7087, University of Toronto)
00cvxb145https://ror.org/00cvxb145 ROR identifier (00cvxb145, University of Washington)
01b6kha49https://ror.org/01b6kha49 ROR identifier (01b6kha49, Walter and Eliza Hall Institute of Medical Research)
AB_62842https://scicrunch.org/resolver/AB_62842 SciCrunch identifier (RRID:AB_62842)
AB_10015289https://scicrunch.org/resolver/AB_10015289 SciCrunch identifier (RRID:AB_10015289)
SCR_023662https://scicrunch.org/resolver/SCR_023662 SciCrunch identifier (RRID:SCR_023662, AlphaFold Protein Structure Database)
SCR_025454https://scicrunch.org/resolver/SCR_025454 SciCrunch identifier (RRID:SCR_025454, AlphaFold)
SCR_018209https://scicrunch.org/resolver/SCR_018209 SciCrunch identifier (RRID:SCR_018209, Anndata)
SCR_021643https://scicrunch.org/resolver/SCR_021643 SciCrunch identifier (RRID:SCR_021643, AstraZeneca PheWAS Portal)
SCR_007393https://scicrunch.org/resolver/SCR_007393 SciCrunch identifier (RRID:SCR_007393, Biological General Repository for Interaction Datasets (BioGRID))
SCR_019214https://scicrunch.org/resolver/SCR_019214 SciCrunch identifier (RRID:SCR_019214, biomaRt)
SCR_018361https://scicrunch.org/resolver/SCR_018361 SciCrunch identifier (RRID:SCR_018361, Biorender)
SCR_001591https://scicrunch.org/resolver/SCR_001591 SciCrunch identifier (RRID:SCR_001591, Clustal Omega)
SCR_013433https://scicrunch.org/resolver/SCR_013433 SciCrunch identifier (RRID:SCR_013433, Dali Server)
SCR_012802https://scicrunch.org/resolver/SCR_012802 SciCrunch identifier (RRID:SCR_012802, edgeR)
SCR_002344https://scicrunch.org/resolver/SCR_002344 SciCrunch identifier (RRID:SCR_002344, Ensembl)
SCR_010519https://scicrunch.org/resolver/SCR_010519 SciCrunch identifier (RRID:SCR_010519, Geneious)
SCR_014514https://scicrunch.org/resolver/SCR_014514 SciCrunch identifier (RRID:SCR_014514, Genomic Data Commons Data Portal (GDC Data Portal))
SCR_001618https://scicrunch.org/resolver/SCR_001618 SciCrunch identifier (RRID:SCR_001618, GTEx eQTL Browser)
SCR_006695https://scicrunch.org/resolver/SCR_006695 SciCrunch identifier (RRID:SCR_006695, InterPro)
SCR_018174https://scicrunch.org/resolver/SCR_018174 SciCrunch identifier (RRID:SCR_018174, iTOL)
SCR_010943https://scicrunch.org/resolver/SCR_010943 SciCrunch identifier (RRID:SCR_010943, LIMMA)
SCR_008624https://scicrunch.org/resolver/SCR_008624 SciCrunch identifier (RRID:SCR_008624, MatPlotLib)
SCR_008633https://scicrunch.org/resolver/SCR_008633 SciCrunch identifier (RRID:SCR_008633, NumPy)
SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)
SCR_018139https://scicrunch.org/resolver/SCR_018139 SciCrunch identifier (RRID:SCR_018139, scanpy)
SCR_008058https://scicrunch.org/resolver/SCR_008058 SciCrunch identifier (RRID:SCR_008058, SciPy)
SCR_002380https://scicrunch.org/resolver/SCR_002380 SciCrunch identifier (RRID:SCR_002380, UniProt)
goeseek.gwdguser.de/studies/283https://goeseek.gwdguser.de/studies/283 Supplemental material (goeseek study)
ars.els-...1.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S0092867426001169-mmc1.xlsx Supplemental material (table)