| Property |
Value |
| Working Groups |
RG Oudelaar, 
RG Papantonis |
| Subproject |
P02, P03 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
42481807 |
| DOI |
10.1038/s43587-026-01171-6 |
| Publication Year |
2026 |
| Title |
Senescent cells cluster CTCF on nuclear speckles and instruct an alternative splicing program |
| Journal |
Nature Aging |
| eISSN |
2662-8465 |
| Journal Abbreviation |
Nat Aging |
| Authors |
Palikyras S, Varamogiani-Mamatsi V, Zhu Y, Mizi A , Ramasamy S, Grini JV, Liebermann I, Stavropoulou A, Penagos Puig A, Ogurlu TS, Kydonakis K, Papadionysiou I, Bartsch D, Kargapolova Y, Morero NR, Sofiadis K, Nikolaou C, Kundel F, Kurian L, Ellenberg J, Oudelaar AM, Barbieri M, Beckwith KS, Papantonis A |
| First Author |
Palikyras S |
| Last Author |
Papantonis A |
External Resources
nature.c...-6.pdfhttps://www.nature.com/articles/s43587-026-01171-6.pdf Article fulltext
2/178941https://publications.goettingen-research-online.de/handle/2/178941 GRO.publications identifier
GSE269856https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE269856 NCBI GEO Dataset (GSE269856)
GSE269857https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE269857 NCBI GEO Dataset (GSE269857)
GSE269858https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE269858 NCBI GEO Dataset (GSE269858)
GSE283687https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283687 NCBI GEO Dataset (GSE283687)
GSE98448https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98448 NCBI GEO Dataset (GSE98448, reused)
GSE113957https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113957 NCBI GEO Dataset (GSE113957, reused)
GSE154095https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE154095 NCBI GEO Dataset (GSE154095, reused)
GSE171782https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE171782 NCBI GEO Dataset (GSE171782, reused)
GSE238256https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE238256 NCBI GEO Dataset (GSE238256, reused)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
0000-0002-4470-8284https://orcid.org/0000-0002-4470-8284 ORCID identifier (Spyridon Palikyras)
0009-0006-7800-9920https://orcid.org/0009-0006-7800-9920 ORCID identifier (Vassiliki Varamogianni-Mamatsi)
0000-0003-0617-694Xhttps://orcid.org/0000-0003-0617-694X ORCID identifier (Shyam Ramasamy)
0009-0002-3263-0990https://orcid.org/0009-0002-3263-0990 ORCID identifier (Athanasia Stavropoulou)
0000-0003-3299-8330https://orcid.org/0000-0003-3299-8330 ORCID identifier (Deniz Bartsch)
0000-0001-7541-5778https://orcid.org/0000-0001-7541-5778 ORCID identifier (Yulia Kargapolova)
0009-0000-0167-8372https://orcid.org/0009-0000-0167-8372 ORCID identifier (Konstantinos Sofiadis)
0000-0003-3001-6786https://orcid.org/0000-0003-3001-6786 ORCID identifier (Christoforos Nikolaou)
0000-0001-7466-5169https://orcid.org/0000-0001-7466-5169 ORCID identifier (Leo Kurian)
0000-0002-3425-0476https://orcid.org/0000-0002-3425-0476 ORCID identifier (A. Marieke Oudelaar)
0000-0002-9080-631Xhttps://orcid.org/0000-0002-9080-631X ORCID identifier (Mariano Barbieri)
0000-0001-7551-1073https://orcid.org/0000-0001-7551-1073 ORCID identifier (Argyris Papantonis)
98https://rdp.sfb1565.uni-goettingen.de/literature/publications/98 Published Data Registry entry (CRC 1565, preprint)
5/59https://rdp.sfb1565.uni-goettingen.de/archive/5/59 Research Data Archive (supplemental material)
013x0ky90https://ror.org/013x0ky90 ROR identifier (013x0ky90, Alexander Fleming Biomedical Sciences Research Center)
04cvxnb49https://ror.org/04cvxnb49 ROR identifier (04cvxnb49, Goethe University Frankfurt)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
00rcxh774https://ror.org/00rcxh774 ROR identifier (00rcxh774, University of Cologne)
SCR_006646https://scicrunch.org/resolver/SCR_006646 SciCrunch identifier (RRID:SCR_006646, BEDTools)
SCR_016366https://scicrunch.org/resolver/SCR_016366 SciCrunch identifier (RRID:SCR_016366, Deeptools)
SCR_015687https://scicrunch.org/resolver/SCR_015687 SciCrunch identifier (RRID:SCR_015687, DESeq2)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_002630https://scicrunch.org/resolver/SCR_002630 SciCrunch identifier (RRID:SCR_002630, GitHub)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_005514https://scicrunch.org/resolver/SCR_005514 SciCrunch identifier (RRID:SCR_005514, HTSeq)
SCR_016387https://scicrunch.org/resolver/SCR_016387 SciCrunch identifier (RRID:SCR_016387, Illumina: NovaSeq 6000 Sequencing System)
SCR_016386https://scicrunch.org/resolver/SCR_016386 SciCrunch identifier (RRID:SCR_016386, Illumina HiSeq 3000/HiSeq 4000 System)
SCR_027320https://scicrunch.org/resolver/SCR_027320 SciCrunch identifier (RRID:SCR_027320, IsoformSwitchAnalyzeR)
SCR_021172https://scicrunch.org/resolver/SCR_021172 SciCrunch identifier (RRID:SCR_021172, Juicebox)
SCR_026672https://scicrunch.org/resolver/SCR_026672 SciCrunch identifier (RRID:SCR_026672, Leica DMi8 microscope)
SCR_008335https://scicrunch.org/resolver/SCR_008335 SciCrunch identifier (RRID:SCR_008335, Mayavi: 3D Scientific Data Visualization and Plotting Software Project)
SCR_016620https://scicrunch.org/resolver/SCR_016620 SciCrunch identifier (RRID:SCR_016620, Metascape)
SCR_022765https://scicrunch.org/resolver/SCR_022765 SciCrunch identifier (RRID:SCR_022765, Napari)
SCR_006525https://scicrunch.org/resolver/SCR_006525 SciCrunch identifier (RRID:SCR_006525, Picard)
SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)
SCR_006263https://scicrunch.org/resolver/SCR_006263 SciCrunch identifier (RRID:SCR_006263, RUVSeq)
SCR_017036https://scicrunch.org/resolver/SCR_017036 SciCrunch identifier (RRID:SCR_017036, salmon)
SCR_021142https://scicrunch.org/resolver/SCR_021142 SciCrunch identifier (RRID:SCR_021142, scikit-image)
SCR_004463https://scicrunch.org/resolver/SCR_004463 SciCrunch identifier (RRID:SCR_004463, STAR)
SCR_015872https://scicrunch.org/resolver/SCR_015872 SciCrunch identifier (RRID:SCR_015872, UCSF ChimeraX)
SCR_018349https://scicrunch.org/resolver/SCR_018349 SciCrunch identifier (RRID:SCR_018349, Whippet)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM1_ESM.pdf Supplemental material
git.embl...ptracehttps://git.embl.org/grp-ellenberg/looptrace Supplemental material (code, reused)
github.c...e/BPDLhttps://github.com/marianoimperatore/BPDL Supplemental material (code, reused)
github.com/varamojo/SimChromhttps://github.com/varamojo/SimChrom Supplemental material (code, reused)
goeseek.gwdguser.de/studies/274https://goeseek.gwdguser.de/studies/274 Supplemental material (goeseek study)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM3_ESM.pdf Supplemental material (peer review)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM2_ESM.pdf Supplemental material (reporting summary)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM12_ESM.pdf Supplemental material (source data)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM13_ESM.pdf Supplemental material (source data)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM4_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM5_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM6_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM7_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM8_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM9_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM10_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs43587-026-01171-6/MediaObjects/43587_2026_1171_MOESM11_ESM.xlsx Supplemental material (table)
SCR_021364https://scicrunch.org/resolver/SCR_021364 SciCrunch identifier (RRID:SCR_021364, ZEISS Electron Microscope 900)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0005 |
|
primary |
CTCF |
AB_2614975 |
CTCF antibody (pAb) |
| primary-0015 |
 |
primary |
GFP |
AB_303395 |
Anti-GFP antibody |
| primary-0394 |
|
primary |
SRRM2 |
AB_2647934 |
SRRM2 Polyclonal Antibody |
| primary-0395 |
|
primary |
SRSF2 |
AB_526734 |
SC35 Antibody (SC-35) |
| primary-0430 |
|
primary |
HMGB1 |
AB_3711424 |
Anti-HMGB1 antibody [1F3] |
| secondary-0008 |
|
secondary |
|
AB_2630356 |
Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) |
| secondary-0009 |
|
secondary |
|
AB_10680176 |
Goat Anti-Mouse IgG H&L (Cy3 ®) preadsorbed |
| secondary-0428 |
|
secondary |
|
AB_955021 |
Goat Anti-Rabbit IgG H&L (Cy3 ®) preadsorbed |
| secondary-0431 |
|
secondary |
|
AB_2687948 |
Goat Anti-Mouse IgG H&L (Alexa Fluor® 647) |
| secondary-0432 |
|
secondary |
|
AB_2714032 |
Goat Anti-Rabbit IgG H&L (Alexa Fluor® 647) preadsorbed |
| secondary-0433 |
|
secondary |
|
AB_2813835 |
Donkey Anti-Rat IgG H&L (Alexa Fluor® 647) preadsorbed |
| secondary-0434 |
|
secondary |
|
|
Anti-Rabbit IgG−Abberior® STAR 635 antibody produced in goat |
| secondary-0435 |
|
secondary |
|
|
Anti-Mouse IgG−Abberior® STAR 580 antibody produced in goat |