View publication

↩ Back to all publications
Publication
PropertyValue
Working Groups RG Lenz, RG Lorenz, RG Papantonis, RG Urlaub
SubprojectP17
Open AccessOpen Access Yes
Publication TypeJournal Article
Peer ReviewedYes
PMIDPubMed ID 40897715
DOIDOI 10.1038/s41467-025-63442-x
Publication Year2025
TitleSelective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
JournalNature Communications
ISSN2041-1723
eISSN2041-1723
URL https://doi.org/10.1038/s41467-025-63442-x
Issue1
Volume16
Journal AbbreviationNat Commun
AuthorsOrth B, Pohl P, Aust F, Ji Y, Seenivasan A, Dybkov O, Liang XJ, Bock L, Leidner F, Levantovsky S, Schardey P, Sander P, Disch NJ, Trautz ML, Mizi A, Papantonis A, Lenz C, Grubmüller H, Steinchen W, Behrends C, Urlaub H, Gehringer M, Lorenz S
First AuthorOrth B
Last AuthorLorenz S

 External Resources

 nature.c...-x.pdf  Article fulltext

 0000-0003-1577-7309  ORCID identifier (Pavel Pohl)

 0009-0002-2021-7146  ORCID identifier (Florian Aust)

 0000-0002-9741-5119  ORCID identifier (Yanlong Ji)

 0000-0002-4340-5847  ORCID identifier (Ayshwarya Seenivasan)

 0000-0001-6005-7242  ORCID identifier (Olexandr Dybkov)

 0000-0003-4554-7336  ORCID identifier (Lars V. Bock)

 0000-0002-0048-889X  ORCID identifier (Florian Leidner)

 0000-0002-0918-6871  ORCID identifier (Sophie Levantovsky)

 0009-0004-0410-1199  ORCID identifier (Pascal Sander)

 0000-0002-4313-491X  ORCID identifier (Athanasia Mizi)

 0000-0001-7551-1073  ORCID identifier (Argyris Papantonis)

 0000-0002-0946-8166  ORCID identifier (Christof Lenz)

 0000-0002-3270-3144  ORCID identifier (Helmut Grubmüller)

 0000-0003-2990-3660  ORCID identifier (Wieland Steinchen)

 0000-0002-9184-7607  ORCID identifier (Christian Behrends)

 0000-0003-1837-5233  ORCID identifier (Henning Urlaub)

 0000-0002-9639-2381  ORCID identifier (Sonja Gisela Lorenz)

 PXD063550  Pride proteome dataset (PXD063550)

 PXD066563  Pride proteome dataset (PXD066563)

 PXD067088  Pride proteome dataset (PXD067088)

 398  Published Data Registry entry (CRC 1286)

 5/24  Research Data Archive (supplemental material)

 03av75f26  ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)

 025z3z560  ROR identifier (025z3z560, Munich Cluster for Systems Neurology)

 01rdrb571  ROR identifier (01rdrb571, Philipps University of Marburg)

 021ft0n22  ROR identifier (021ft0n22, University Medical Center Göttingen)

 03a1kwz48  ROR identifier (03a1kwz48, University of Tübingen)

 CVCL_0063  SciCrunch identifier (RRID:CVCL_0063, HEK293T)

 SCR_025454  SciCrunch identifier (RRID:SCR_025454, AlphaFold)

 SCR_002798  SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_014565  SciCrunch identifier (RRID:SCR_014565, GROMACS)

 SCR_013715  SciCrunch identifier (RRID:SCR_013715, Image Studio Lite)

 SCR_013673  SciCrunch identifier (RRID:SCR_013673, Leica Application Suite X)

 SCR_014485  SciCrunch identifier (RRID:SCR_014485, MaxQuant)

 SCR_014212  SciCrunch identifier (RRID:SCR_014212, Origin)

 SCR_015753  SciCrunch identifier (RRID:SCR_015753, Perseus)

 SCR_016664  SciCrunch identifier (RRID:SCR_016664, ProteinLynx Global Server)

 SCR_000305  SciCrunch identifier (RRID:SCR_000305, PyMOL)

 SCR_008394  SciCrunch identifier (RRID:SCR_008394, Python)

 SCR_014593  SciCrunch identifier (RRID:SCR_014593, Thermo Xcalibur)

 static-c...SM.pdf  Supplemental material

 static-c...SM.pdf  Supplemental material

 goeseek.gwdguser.de/studies/247  Supplemental material (goeseek study)

 static-c...SM.pdf  Supplemental material (peer review)

 static-c...SM.pdf  Supplemental material (reporting summary)

 static-c...M.xlsx  Supplemental material (source data)

 static-c...M.xlsx  Supplemental material (table)

 static-c...M.xlsx  Supplemental material (table)

 10.5281/zenodo.15772692  Zenodo identifier (10.5281/zenodo.15772692)

Linked Antibodies

PIDAGTypeAntigen symbolAntibody Registry IDName
primary-0132primaryAB_2940834PTMScan® Ubiquitin Remnant Motif (K-ε-GG) Kit
primary-0163primaryACTBAB_476692Anti-β-Actin antibody
primary-0164primaryHUWE1AB_10922588HECTH9 (AX8D1) Mouse mAb
primary-0165primaryMCL1AB_2722740Mcl-1 (D2W9E) Rabbit mAb
primary-0166primaryHAAB_439705Monoklonaler ANTI-HA-Antikörper
secondary-0167secondaryAB_2099233Anti-rabbit IgG, HRP-linked Antibody
secondary-0168secondaryAB_330924Anti-mouse IgG, HRP-linked Antibody