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Publication

Property	Value
Working Groups	RG Hillen, RG Rehling, RG Richter-Dennerlein
Subproject	P13, P14, P19
Open Access	Yes
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	40240327
DOI	10.1038/s41467-025-58827-x
Publication Year	2025
Title	Coupling of ribosome biogenesis and translation initiation in human mitochondria
Journal	Nature Communications
ISSN	2041-1723
eISSN	2041-1723
URL	https://doi.org/10.1038/s41467-025-58827-x
Issue	1
Volume	16
Journal Abbreviation	Nat Commun
Authors	Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R
First Author	Heinrichs M
Last Author	Richter-Dennerlein R

External Resources

nature.c...-x.pdfhttps://www.nature.com/articles/s41467-025-58827-x.pdf Article fulltext

EMD-51039https://www.ebi.ac.uk/pdbe/emdb/EMD-51039 EMBL-EBI EMDB identifier (EMD-51039)

EMD-51042https://www.ebi.ac.uk/pdbe/emdb/EMD-51042 EMBL-EBI EMDB identifier (EMD-51042)

EMD-51043https://www.ebi.ac.uk/pdbe/emdb/EMD-51043 EMBL-EBI EMDB identifier (EMD-51043)

EMD-51045https://www.ebi.ac.uk/pdbe/emdb/EMD-51045 EMBL-EBI EMDB identifier (EMD-51045)

EMD-51046https://www.ebi.ac.uk/pdbe/emdb/EMD-51046 EMBL-EBI EMDB identifier (EMD-51046)

EMD-51047https://www.ebi.ac.uk/pdbe/emdb/EMD-51047 EMBL-EBI EMDB identifier (EMD-51047)

EMD-51048https://www.ebi.ac.uk/pdbe/emdb/EMD-51048 EMBL-EBI EMDB identifier (EMD-51048)

EMD-51049https://www.ebi.ac.uk/pdbe/emdb/EMD-51049 EMBL-EBI EMDB identifier (EMD-51049)

EMD-51050https://www.ebi.ac.uk/pdbe/emdb/EMD-51050 EMBL-EBI EMDB identifier (EMD-51050)

EMD-51051https://www.ebi.ac.uk/pdbe/emdb/EMD-51051 EMBL-EBI EMDB identifier (EMD-51051)

EMD-51052https://www.ebi.ac.uk/pdbe/emdb/EMD-51052 EMBL-EBI EMDB identifier (EMD-51052)

EMD-51053https://www.ebi.ac.uk/pdbe/emdb/EMD-51053 EMBL-EBI EMDB identifier (EMD-51053)

EMD-51054https://www.ebi.ac.uk/pdbe/emdb/EMD-51054 EMBL-EBI EMDB identifier (EMD-51054)

EMD-51055https://www.ebi.ac.uk/pdbe/emdb/EMD-51055 EMBL-EBI EMDB identifier (EMD-51055)

EMD-51056https://www.ebi.ac.uk/pdbe/emdb/EMD-51056 EMBL-EBI EMDB identifier (EMD-51056)

EMD-51057https://www.ebi.ac.uk/pdbe/emdb/EMD-51057 EMBL-EBI EMDB identifier (EMD-51057)

EMD-51058https://www.ebi.ac.uk/pdbe/emdb/EMD-51058 EMBL-EBI EMDB identifier (EMD-51058)

EMD-51059https://www.ebi.ac.uk/pdbe/emdb/EMD-51059 EMBL-EBI EMDB identifier (EMD-51059)

EMD-51060https://www.ebi.ac.uk/pdbe/emdb/EMD-51060 EMBL-EBI EMDB identifier (EMD-51060)

EMD-51061https://www.ebi.ac.uk/pdbe/emdb/EMD-51061 EMBL-EBI EMDB identifier (EMD-51061)

EMD-51062https://www.ebi.ac.uk/pdbe/emdb/EMD-51062 EMBL-EBI EMDB identifier (EMD-51062)

EMD-51063https://www.ebi.ac.uk/pdbe/emdb/EMD-51063 EMBL-EBI EMDB identifier (EMD-51063)

EMD-51064https://www.ebi.ac.uk/pdbe/emdb/EMD-51064 EMBL-EBI EMDB identifier (EMD-51064)

EMD-51065https://www.ebi.ac.uk/pdbe/emdb/EMD-51065 EMBL-EBI EMDB identifier (EMD-51065)

EMD-51066https://www.ebi.ac.uk/pdbe/emdb/EMD-51066 EMBL-EBI EMDB identifier (EMD-51066)

EMD-51083https://www.ebi.ac.uk/pdbe/emdb/EMD-51083 EMBL-EBI EMDB identifier (EMD-51083)

EMD-51084https://www.ebi.ac.uk/pdbe/emdb/EMD-51084 EMBL-EBI EMDB identifier (EMD-51084)

EMD-51085https://www.ebi.ac.uk/pdbe/emdb/EMD-51085 EMBL-EBI EMDB identifier (EMD-51085)

EMD-51086https://www.ebi.ac.uk/pdbe/emdb/EMD-51086 EMBL-EBI EMDB identifier (EMD-51086)

EMD-52117https://www.ebi.ac.uk/pdbe/emdb/EMD-52117 EMBL-EBI EMDB identifier (EMD-52117)

EMD-52118https://www.ebi.ac.uk/pdbe/emdb/EMD-52118 EMBL-EBI EMDB identifier (EMD-52118)

EMD-52119https://www.ebi.ac.uk/pdbe/emdb/EMD-52119 EMBL-EBI EMDB identifier (EMD-52119)

gro-2/148941http://resolver.sub.uni-goettingen.de/purl?gro-2/148941 GRO.publications identifier

0009-0001-2773-6726https://orcid.org/0009-0001-2773-6726 ORCID identifier (Marleen Heinrichs)

0000-0001-5972-9865https://orcid.org/0000-0001-5972-9865 ORCID identifier (Anna Franziska Finke)

0000-0003-2221-482Xhttps://orcid.org/0000-0003-2221-482X ORCID identifier (Shintaro Aibara)

0009-0008-3572-0223https://orcid.org/0009-0008-3572-0223 ORCID identifier (Angela Boshnakovska)

0000-0001-5661-5272https://orcid.org/0000-0001-5661-5272 ORCID identifier (Peter Rehling)

0000-0002-1206-0129https://orcid.org/0000-0002-1206-0129 ORCID identifier (Hauke Sven Hillen)

0000-0001-8904-1543https://orcid.org/0000-0001-8904-1543 ORCID identifier (Ricarda Richter-Dennerlein)

265https://sfb1190.med.uni-goettingen.de/production/literature/publications/265 Published Data Registry entry (CRC 1190)

72https://for2848.gwdguser.de/literature/publications/72 Published Data Registry entry (FOR 2848)

1204https://prod.mbexc.uni-goettingen.de/literature/publications/1204 Published Data Registry entry (MBExC)

9G5Bhttps://www.rcsb.org/structure/9G5B RCSB PDB Identifier (DOI:10.2210/pdb9G5B/pdb)

9G5Chttps://www.rcsb.org/structure/9G5C RCSB PDB Identifier (DOI:10.2210/pdb9G5C/pdb)

9G5Dhttps://www.rcsb.org/structure/9G5D RCSB PDB Identifier (DOI:10.2210/pdb9G5D/pdb)

9G5Ehttps://www.rcsb.org/structure/9G5E RCSB PDB Identifier (DOI:10.2210/pdb9G5E/pdb)

9HFMhttps://www.rcsb.org/structure/9HFM RCSB PDB Identifier (DOI:10.2210/pdb9HFM/pdb)

9HFNhttps://www.rcsb.org/structure/9HFN RCSB PDB Identifier (DOI:10.2210/pdb9HFN/pdb)

9HFOhttps://www.rcsb.org/structure/9HFO RCSB PDB Identifier (DOI:10.2210/pdb9HFO/pdb)

3J9Mhttps://www.rcsb.org/structure/3J9M RCSB PDB Identifier (DOI:10.2210/pdb3J9M/pdb, reused)

6GAWhttps://www.rcsb.org/structure/6GAW RCSB PDB Identifier (DOI:10.2210/pdb6GAW/pdb, reused)

6RW5https://www.rcsb.org/structure/6RW5 RCSB PDB Identifier (DOI:10.2210/pdb6RW5/pdb, reused)

7PNThttps://www.rcsb.org/structure/7PNT RCSB PDB Identifier (DOI:10.2210/pdb7PNT/pdb, reused)

7PNXhttps://www.rcsb.org/structure/7PNX RCSB PDB Identifier (DOI:10.2210/pdb7PNX/pdb, reused)

7PO1https://www.rcsb.org/structure/7PO1 RCSB PDB Identifier (DOI:10.2210/pdb7PO1/pdb, reused)

7PO2https://www.rcsb.org/structure/7PO2 RCSB PDB Identifier (DOI:10.2210/pdb7PO2/pdb, reused)

8CSPhttps://www.rcsb.org/structure/8CSP RCSB PDB Identifier (DOI:10.2210/pdb8CSP/pdb, reused)

8CSRhttps://www.rcsb.org/structure/8CSR RCSB PDB Identifier (DOI:10.2210/pdb8CSR/pdb, reused)

1/592https://mbexc.uni-goettingen.de/archive/1/592 Research Data Archive MBExC (supplemental material)

01s1h3j07https://ror.org/01s1h3j07 ROR identifier (01s1h3j07, Fraunhofer Institute for Translational Medicine and Pharmacology)

03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)

05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)

CVCL_0045https://scicrunch.org/resolver/CVCL_0045 SciCrunch identifier (RRID:CVCL_0045, HEK293)

SCR_014222https://scicrunch.org/resolver/SCR_014222 SciCrunch identifier (RRID:SCR_014222, Coot)

SCR_016501https://scicrunch.org/resolver/SCR_016501 SciCrunch identifier (RRID:SCR_016501, cryoSPARC)

SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)

SCR_025577https://scicrunch.org/resolver/SCR_025577 SciCrunch identifier (RRID:SCR_025577, ISOLDE)

SCR_003420https://scicrunch.org/resolver/SCR_003420 SciCrunch identifier (RRID:SCR_003420, nSolver)

SCR_016274https://scicrunch.org/resolver/SCR_016274 SciCrunch identifier (RRID:SCR_016274, RELION)

SCR_017293https://scicrunch.org/resolver/SCR_017293 SciCrunch identifier (RRID:SCR_017293, SerialEM)

SCR_015872https://scicrunch.org/resolver/SCR_015872 SciCrunch identifier (RRID:SCR_015872, UCSF ChimeraX)

SCR_018071https://scicrunch.org/resolver/SCR_018071 SciCrunch identifier (RRID:SCR_018071, Warp)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-58827-x/MediaObjects/41467_2025_58827_MOESM1_ESM.pdf Supplemental material

goeseek.gwdguser.de/studies/235https://goeseek.gwdguser.de/studies/235 Supplemental material (goeseek study)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-58827-x/MediaObjects/41467_2025_58827_MOESM3_ESM.pdf Supplemental material (peer review)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-58827-x/MediaObjects/41467_2025_58827_MOESM2_ESM.pdf Supplemental material (reporting summary)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-58827-x/MediaObjects/41467_2025_58827_MOESM4_ESM.xlsx Supplemental material (source data)

Linked Antibodies

PID	Type	Antigen symbol	Antibody Registry ID	Name
primary-0034	primary	MRPS18B	AB_2146368	MRPS18B antibody
primary-0035	primary	MRPS7	AB_1854132	Anti-MRPS7 antibody
primary-0036	primary	MRPS14	AB_2878240	MRPS14 Polyclonal antibody
primary-0038	primary	MRPS25	AB_2180358	MRPS25 Polyclonal antibody
primary-0039	primary	MRPS27	AB_2180510	MRPS27 Polyclonal antibody
primary-0042	primary	MRPL13	AB_2145705	MRPL13 Polyclonal antibody
primary-0046	primary	CANX	AB_2882231	Calnexin Monoclonal antibody
primary-0049	primary	uL23m		anti-uL23m
primary-0051	primary	COX1		anti-COX1
primary-0053	primary	SDHA	AB_10838019	SDHA Monoclonal Antibody (2E3GC12FB2AE2)
primary-0081	primary	CHCHD1	AB_2079769	CHCHD1 Polyklonaler Antikörper
primary-0082	primary	MRPS35	AB_2146521	MRPS35 Polyklonaler Antikörper
primary-0083	primary	MRPS34	AB_2144233	MRPS34 Polyklonaler Antikörper
primary-0085	primary	DAP3	AB_10695891	DAP3 Polyklonaler Antikörper
primary-0086	primary	MRPS23	AB_2301078	MRPS23 Polyclonal antibody
primary-0087	primary	MRPS22	AB_2146488	MRPS22 Polyklonaler Antikörper
primary-0088	primary	MRPS17	AB_10597844	MRPS17 Polyclonal antibody
primary-0089	primary	PPWD1	AB_2237509	PPWD1 Polyklonaler Antikörper
primary-0092	primary	MRPS10	AB_2254095	MRPS10 Polyklonaler Antikörper
primary-0094	primary	MRPS5	AB_2878258	MRPS5 Polyklonaler Antikörper
primary-0095	primary	MRPS28	AB_2180748	MRPS28 Polyklonaler Antikörper
primary-0122	primary	ATP6	AB_2881305	ATP6 Polyklonaler Antikörper
primary-0175	primary	MT-CO2	AB_10887758	Anti-MTCO2 antibody
primary-0176	primary	GAPDH	AB_627679	Anti-GAPDH Antibody
primary-0177	primary	NSUN4		NSUN4 Polyclonal antibody
primary-0178	primary	C4orf14	AB_2639060	C4orf14 Polyclonal Antibody
primary-0179	primary	ERAL1	AB_2098973	ERAL1 Polyklonaler Antikörper
primary-0180	primary	TFB1M	AB_3085501	TFB1M Polyklonaler Antikörper
primary-0181	primary	RBFA	AB_11009967	RBFA Antibody - BSA Free
primary-0182	primary	mtIF2		Rabbit polyclonal anti-mtIF2
primary-0183	primary	MTIF3	AB_10638621	MTIF3 Polyklonaler Antikörper
primary-0184	primary	LRPPRC	AB_10733879	LRPPRC Polyklonaler Antikörper
secondary-0125	secondary		AB_2307392	Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)
secondary-0185	secondary		AB_621847	IRDye® 800CW Donkey anti-Mouse IgG Secondary Antibody
secondary-0186	secondary		AB_621848	IRDye® 800CW Donkey anti-Rabbit IgG Secondary Antibody
secondary-0187	secondary		AB_2307391	Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)

Department of Medical Informatics
University Medical Center Göttingen
Imprint

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External Resources

Linked Antibodies

Technical support

Links

Speaker

Prof. Dr. Markus T. Bohnsack

Speaker of SFB1565