| Property |
Value |
| Working Groups |
RG Bohnsack K.E., 
RG Bohnsack M.T., 
RG Dobbelstein, 
RG Lenz, 
RG Urlaub |
| Subproject |
P04, P06, P08, P12 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
42557376 |
| DOI |
10.1038/s41418-026-01834-2 |
| Publication Year |
2026 |
| Title |
MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA |
| Journal |
Cell Death and Differentiation |
| ISSN |
1350-9047 |
| eISSN |
1476-5403 |
| URL |
https://doi.org/10.1038/s41418-026-01834-2 |
| Journal Abbreviation |
Cell Death Differ |
| Authors |
Weber S, Manzini V, Dietrich H, Schotte H, Moshkovskii S, Hackert P, Duman ET, Vu NQ, Prokakis E, Salinas G, Lenz C, Urlaub H, Bohnsack KE, Bohnsack MT, Dobbelstein M |
| First Author |
Weber S |
| Last Author |
Dobbelstein M |
External Resources
nature.c...-2.pdfhttps://www.nature.com/articles/s41418-026-01834-2.pdf Article fulltext
MSV000100118https://massive.ucsd.edu/ProteoSAFe/QueryMSV?id=MSV000100118 MassIVE identifier (MSV000100118, DOI: 10.25345/C58C9RH7D)
GSE334227https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334227 NCBI GEO Dataset (GSE334227)
GSE333484https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333484 NCBI GEO Dataset (GSE333484)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
0009-0002-8612-5420https://orcid.org/0009-0002-8612-5420 ORCID identifier (Sabrina Weber)
0000-0003-2248-6753https://orcid.org/0000-0003-2248-6753 ORCID identifier (Valentina Manzini)
0000-0003-1697-9201https://orcid.org/0000-0003-1697-9201 ORCID identifier (Sergei Moshkovskii)
0000-0002-3957-9369https://orcid.org/0000-0002-3957-9369 ORCID identifier (Emre Taylan Duman)
0000-0001-9297-1821https://orcid.org/0000-0001-9297-1821 ORCID identifier (Evangelos Prokakis)
0000-0001-8269-2669https://orcid.org/0000-0001-8269-2669 ORCID identifier (Gabriela Salinas-Riester)
0000-0002-0946-8166https://orcid.org/0000-0002-0946-8166 ORCID identifier (Christof Lenz)
0000-0003-1837-5233https://orcid.org/0000-0003-1837-5233 ORCID identifier (Henning Urlaub)
0000-0001-6035-4255https://orcid.org/0000-0001-6035-4255 ORCID identifier (Katherine Elizabeth Bohnsack)
0000-0001-7063-5456https://orcid.org/0000-0001-7063-5456 ORCID identifier (Markus T. Bohnsack)
0000-0001-5052-3967https://orcid.org/0000-0001-5052-3967 ORCID identifier (Matthias Dobbelstein)
PXD071637http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD071637 Pride proteome dataset (PXD071637)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)
CVCL_U614https://scicrunch.org/resolver/CVCL_U614 SciCrunch identifier (RRID:CVCL_U614, 93T449)
CVCL_M819https://scicrunch.org/resolver/CVCL_M819 SciCrunch identifier (RRID:CVCL_M819, GOT3)
CVCL_4388https://scicrunch.org/resolver/CVCL_4388 SciCrunch identifier (RRID:CVCL_4388, hTERT-RPE1)
CVCL_0060https://scicrunch.org/resolver/CVCL_0060 SciCrunch identifier (RRID:CVCL_0060, NCI-H1299)
CVCL_0598https://scicrunch.org/resolver/CVCL_0598 SciCrunch identifier (RRID:CVCL_0598, MCF-10A)
CVCL_0031https://scicrunch.org/resolver/CVCL_0031 SciCrunch identifier (RRID:CVCL_0031, MCF7)
CVCL_1697https://scicrunch.org/resolver/CVCL_1697 SciCrunch identifier (RRID:CVCL_1697, SJSA-1)
SCR_007173https://scicrunch.org/resolver/SCR_007173 SciCrunch identifier (RRID:SCR_007173, Biopython)
SCR_018361https://scicrunch.org/resolver/SCR_018361 SciCrunch identifier (RRID:SCR_018361, Biorender)
SCR_001456https://scicrunch.org/resolver/SCR_001456 SciCrunch identifier (RRID:SCR_001456, BD FACSDiva Software)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_006281https://scicrunch.org/resolver/SCR_006281 SciCrunch identifier (RRID:SCR_006281, Galaxy)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_014210https://scicrunch.org/resolver/SCR_014210 SciCrunch identifier (RRID:SCR_014210, Image Lab Software)
SCR_008394https://scicrunch.org/resolver/SCR_008394 SciCrunch identifier (RRID:SCR_008394, Python)
SCR_021017https://scicrunch.org/resolver/SCR_021017 SciCrunch identifier (RRID:SCR_021017, pysam)
SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)
SCR_013672https://scicrunch.org/resolver/SCR_013672 SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)
media.sp...SM.pdfhttps://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41418-026-01834-2/MediaObjects/41418_2026_1834_MOESM1_ESM.pdf Supplemental material (figure)
media.sp...M.pptxhttps://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41418-026-01834-2/MediaObjects/41418_2026_1834_MOESM8_ESM.pptx Supplemental material (source data)
media.sp...M.xlsxhttps://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41418-026-01834-2/MediaObjects/41418_2026_1834_MOESM2_ESM.xlsx Supplemental material (table)
media.sp...M.xlsxhttps://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41418-026-01834-2/MediaObjects/41418_2026_1834_MOESM3_ESM.xlsx Supplemental material (table)
media.sp...M.xlsxhttps://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41418-026-01834-2/MediaObjects/41418_2026_1834_MOESM4_ESM.xlsx Supplemental material (table)
media.sp...M.xlsxhttps://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41418-026-01834-2/MediaObjects/41418_2026_1834_MOESM5_ESM.xlsx Supplemental material (table)
media.sp...M.xlsxhttps://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41418-026-01834-2/MediaObjects/41418_2026_1834_MOESM6_ESM.xlsx Supplemental material (table)
media.sp...M.xlsxhttps://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41418-026-01834-2/MediaObjects/41418_2026_1834_MOESM7_ESM.xlsx Supplemental material (table)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0226 |
|
primary |
GAPDH |
AB_2107448 |
Anti-GAPDH antibody [6C5] |
| primary-0227 |
|
primary |
MDM2 |
AB_564803 |
Anti-MDM2 (Ab-1) Mouse mAb (IF2) |
| primary-0229 |
|
primary |
CDN1A |
AB_823586 |
p21 Waf1/Cip1 (12D1) Rabbit Monoclonal Antibody |
| primary-0230 |
|
primary |
TP53 |
AB_628082 |
Anti-p53 Antibody (DO-1) |
| primary-0441 |
|
primary |
HS71A |
AB_2279841 |
HSP70 Antibody |
| primary-0442 |
|
primary |
|
AB_2687657 |
Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) |
| primary-0443 |
|
primary |
IRF3 |
AB_2127004 |
IRF3 Polyklonaler Antikörper |
| primary-0444 |
|
primary |
MDM2 |
AB_564810 |
Anti-MDM2 (Ab-3) Mouse mAb (4B11) |
| primary-0445 |
|
primary |
MX1 |
|
Anti-MX1 antibody [EPR19967] |
| primary-0446 |
|
primary |
PARP1 |
|
PARP Antibody |
| primary-0447 |
|
primary |
POLR3A |
AB_2645765 |
POLR3A Polyclonal Antibody |
| primary-0448 |
|
primary |
POLR3A |
|
Anti-POLR3A antibody |
| primary-0449 |
|
primary |
TBK1 |
AB_10693472 |
Phospho-TBK1/NAK (Ser172) (D52C2) Rabbit Monoclonal Antibody |
| primary-0450 |
|
primary |
RIG-I |
AB_2721902 |
Anti-RIG-I/DDX58 antibody [EPR18629] |
| primary-0451 |
|
primary |
TMEM173 |
AB_2127004 |
TMEM173/STING Polyklonaler Antikörper |
| primary-0452 |
|
primary |
TBK1 |
AB_2255663 |
TBK1/NAK (D1B4) Rabbit Monoclonal Antibody |
| primary-0453 |
|
primary |
ACTB |
AB_10665370 |
Anti-beta Actin antibody [AC-15] - Loading Control |
| primary-0454 |
|
primary |
|
AB_430878 |
Anti-β-Galactosidase mAb |
| secondary-0126 |
 |
secondary |
|
AB_2534088 |
Goat anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0221 |
|
secondary |
|
AB_2340773 |
Peroxidase AffiniPure® F(ab')₂ Fragment Donkey Anti-Mouse IgG (H+L) |
| secondary-0222 |
|
secondary |
|
AB_2340590 |
Peroxidase AffiniPure® F(ab')₂ Fragment Donkey Anti-Rabbit IgG (H+L) |
| secondary-0440 |
|
secondary |
|
AB_143157 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 568 |