| Property |
Value |
| Working Groups |
RG Dobbelstein, 
RG Oudelaar, 
RG Papantonis |
| Subproject |
P02, P03, P08 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
42636797 |
| DOI |
10.1016/j.celrep.2026.117649 |
| Publication Year |
2026 |
| Title |
Targeting addiction to HMGB2-driven transcriptional programs in pancreatic cancer |
| Journal |
Cell Reports |
| ISSN |
2211-1247 |
| eISSN |
2211-1247 |
| URL |
https://doi.org/10.1016/j.celrep.2026.117649 |
| Pages |
117649 |
| Journal Abbreviation |
Cell Reports |
| Authors |
Danieli-Mackay A, Papadionysiou I, Tsitsianopoulos M, Gätje FB, Spahn H, Schmidt C, Klein L, Ramasamy S, Übelmesser N, Appelhans J, Dschun O, Duman ET, Ludewig F, Schimkowiak S, Dobbelstein M, Salinas G, Ströbel P, Oudelaar AM, de Oliveira T, Singh SK, Längst G, Conradi LC, Papantonis A |
| First Author |
Danieli-Mackay A |
| Last Author |
Papantonis A |
External Resources
scienced...in.pdfhttps://www.sciencedirect.com/science/article/pii/S2211124726007278/pdfft?md5=a8ac39b216587bae8211680566173c4f&pid=1-s2.0-S2211124726007278-main.pdf Article fulltext
2/179619https://publications.goettingen-research-online.de/handle/2/179619 GRO.publications identifier
GSE296280https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296280 NCBI GEO Dataset (GSE296280)
GSE125588https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125588 NCBI GEO Dataset (GSE125588, reused)
GSE269858https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE269858 NCBI GEO Dataset (GSE269858, reused)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
0000-0001-7337-3797https://orcid.org/0000-0001-7337-3797 ORCID identifier (Adi Danieli-Mackay)
0009-0003-6382-1252https://orcid.org/0009-0003-6382-1252 ORCID identifier (Markos Tsitsianopoulos)
0009-0005-8164-9868https://orcid.org/0009-0005-8164-9868 ORCID identifier (Fabio Bennet Gätje)
0009-0005-5274-7514https://orcid.org/0009-0005-5274-7514 ORCID identifier (Lukas Klein)
0000-0003-0617-694Xhttps://orcid.org/0000-0003-0617-694X ORCID identifier (Shyam Ramasamy)
0000-0003-3141-1526https://orcid.org/0000-0003-3141-1526 ORCID identifier (Nadine Übelmesser)
0000-0002-3957-9369https://orcid.org/0000-0002-3957-9369 ORCID identifier (Emre Taylan Duman)
0009-0005-0806-0467https://orcid.org/0009-0005-0806-0467 ORCID identifier (Fabian Ludewig)
0000-0001-5052-3967https://orcid.org/0000-0001-5052-3967 ORCID identifier (Matthias Dobbelstein)
0000-0001-8269-2669https://orcid.org/0000-0001-8269-2669 ORCID identifier (Gabriela Salinas-Riester)
0000-0002-8528-8060https://orcid.org/0000-0002-8528-8060 ORCID identifier (Philipp Ströbel)
0000-0002-3425-0476https://orcid.org/0000-0002-3425-0476 ORCID identifier (A. Marieke Oudelaar)
0000-0002-2502-7897https://orcid.org/0000-0002-2502-7897 ORCID identifier (Tiago de Oliveira)
0000-0002-9488-1018https://orcid.org/0000-0002-9488-1018 ORCID identifier (Lena-Christin Conradi)
0000-0001-7551-1073https://orcid.org/0000-0001-7551-1073 ORCID identifier (Argyris Papantonis)
5/60https://rdp.sfb1565.uni-goettingen.de/archive/5/60 Research Data Archive (supplemental material)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
01eezs655https://ror.org/01eezs655 ROR identifier (01eezs655, University of Regensburg)
AB_141370https://scicrunch.org/resolver/AB_141370 SciCrunch identifier (RRID:AB_141370)
AB_627761https://scicrunch.org/resolver/AB_627761 SciCrunch identifier (RRID:AB_627761)
AB_955021https://scicrunch.org/resolver/AB_955021 SciCrunch identifier (RRID:AB_955021)
AB_628110https://scicrunch.org/resolver/AB_628110 SciCrunch identifier (RRID:AB_628110)
AB_955439https://scicrunch.org/resolver/AB_955439 SciCrunch identifier (RRID:AB_955439)
AB_955447https://scicrunch.org/resolver/AB_955447 SciCrunch identifier (RRID:AB_955447)
AB_1140885https://scicrunch.org/resolver/AB_1140885 SciCrunch identifier (RRID:AB_1140885)
AB_2191222https://scicrunch.org/resolver/AB_2191222 SciCrunch identifier (RRID:AB_2191222)
AB_2534016https://scicrunch.org/resolver/AB_2534016 SciCrunch identifier (RRID:AB_2534016)
AB_2576208https://scicrunch.org/resolver/AB_2576208 SciCrunch identifier (RRID:AB_2576208)
AB_2630356https://scicrunch.org/resolver/AB_2630356 SciCrunch identifier (RRID:AB_2630356)
CVCL_0186https://scicrunch.org/resolver/CVCL_0186 SciCrunch identifier (RRID:CVCL_0186, BxPC-3)
CVCL_0237https://scicrunch.org/resolver/CVCL_0237 SciCrunch identifier (RRID:CVCL_0237, Capan-1)
CVCL_0428https://scicrunch.org/resolver/CVCL_0428 SciCrunch identifier (RRID:CVCL_0428, MIA PaCa-2)
CVCL_0480https://scicrunch.org/resolver/CVCL_0480 SciCrunch identifier (RRID:CVCL_0480, PANC-1)
CVCL_1847https://scicrunch.org/resolver/CVCL_1847 SciCrunch identifier (RRID:CVCL_1847, PaTu 8988t)
IMSR_JAX:007799https://scicrunch.org/resolver/IMSR_JAX:007799 SciCrunch identifier (RRID:IMSR_JAX:007799, NOD.Cg-Rag1tm1Mom Il2rg/SzJ)
IMSR_RJ:NMRI-NUDEhttps://scicrunch.org/resolver/IMSR_RJ:NMRI-NUDE SciCrunch identifier (RRID:IMSR_RJ:NMRI-NUDE, Rj:NMRI-Foxn1nu/nu)
SCR_025848https://scicrunch.org/resolver/SCR_025848 SciCrunch identifier (RRID:SCR_025848, 10x Genomics Space Ranger)
SCR_001456https://scicrunch.org/resolver/SCR_001456 SciCrunch identifier (RRID:SCR_001456, BD FACSDiva Software)
SCR_006646https://scicrunch.org/resolver/SCR_006646 SciCrunch identifier (RRID:SCR_006646, BEDTools)
SCR_010910https://scicrunch.org/resolver/SCR_010910 SciCrunch identifier (RRID:SCR_010910, BWA)
SCR_017344https://scicrunch.org/resolver/SCR_017344 SciCrunch identifier (RRID:SCR_017344, Cell Ranger)
SCR_002141https://scicrunch.org/resolver/SCR_002141 SciCrunch identifier (RRID:SCR_002141, circlize)
SCR_016884https://scicrunch.org/resolver/SCR_016884 SciCrunch identifier (RRID:SCR_016884, clusterProfiler)
SCR_024194https://scicrunch.org/resolver/SCR_024194 SciCrunch identifier (RRID:SCR_024194, Cooler)
SCR_026118https://scicrunch.org/resolver/SCR_026118 SciCrunch identifier (RRID:SCR_026118, cooltools)
SCR_016366https://scicrunch.org/resolver/SCR_016366 SciCrunch identifier (RRID:SCR_016366, Deeptools)
SCR_012802https://scicrunch.org/resolver/SCR_012802 SciCrunch identifier (RRID:SCR_012802, edgeR)
SCR_012919https://scicrunch.org/resolver/SCR_012919 SciCrunch identifier (RRID:SCR_012919, featureCounts)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_014601https://scicrunch.org/resolver/SCR_014601 SciCrunch identifier (RRID:SCR_014601, ggplot2)
SCR_002630https://scicrunch.org/resolver/SCR_002630 SciCrunch identifier (RRID:SCR_002630, GitHub)
SCR_017643https://scicrunch.org/resolver/SCR_017643 SciCrunch identifier (RRID:SCR_017643, HiC-Pro)
SCR_010881https://scicrunch.org/resolver/SCR_010881 SciCrunch identifier (RRID:SCR_010881, HOMER)
SCR_018555https://scicrunch.org/resolver/SCR_018555 SciCrunch identifier (RRID:SCR_018555, Loupe Browser)
SCR_013291https://scicrunch.org/resolver/SCR_013291 SciCrunch identifier (RRID:SCR_013291, MACS)
SCR_016620https://scicrunch.org/resolver/SCR_016620 SciCrunch identifier (RRID:SCR_016620, Metascape)
SCR_016863https://scicrunch.org/resolver/SCR_016863 SciCrunch identifier (RRID:SCR_016863, MSigDB)
SCR_003002https://scicrunch.org/resolver/SCR_003002 SciCrunch identifier (RRID:SCR_003002, NOISeq)
SCR_023038https://scicrunch.org/resolver/SCR_023038 SciCrunch identifier (RRID:SCR_023038, pairtools)
SCR_027916https://scicrunch.org/resolver/SCR_027916 SciCrunch identifier (RRID:SCR_027916, peakachu)
SCR_016418https://scicrunch.org/resolver/SCR_016418 SciCrunch identifier (RRID:SCR_016418, pheatmap)
SCR_021396https://scicrunch.org/resolver/SCR_021396 SciCrunch identifier (RRID:SCR_021396, plotgardener)
SCR_025758https://scicrunch.org/resolver/SCR_025758 SciCrunch identifier (RRID:SCR_025758, Prometheus)
SCR_018257https://scicrunch.org/resolver/SCR_018257 SciCrunch identifier (RRID:SCR_018257, QuPath)
SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)
SCR_006263https://scicrunch.org/resolver/SCR_006263 SciCrunch identifier (RRID:SCR_006263, RUVSeq)
SCR_002105https://scicrunch.org/resolver/SCR_002105 SciCrunch identifier (RRID:SCR_002105, Samtools)
SCR_007322https://scicrunch.org/resolver/SCR_007322 SciCrunch identifier (RRID:SCR_007322, Seurat)
SCR_021158https://scicrunch.org/resolver/SCR_021158 SciCrunch identifier (RRID:SCR_021158 Signac)
SCR_024742https://scicrunch.org/resolver/SCR_024742 SciCrunch identifier (RRID:SCR_024742, SingleCellNet)
SCR_015899https://scicrunch.org/resolver/SCR_015899 SciCrunch identifier (RRID:SCR_015899, STAR)
SCR_013672https://scicrunch.org/resolver/SCR_013672 SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)
ars.els-...c1.pdfhttps://ars.els-cdn.com/content/image/1-s2.0-S2211124726007278-mmc1.pdf Supplemental material
github.com/anlin00007/OnTADhttps://github.com/anlin00007/OnTAD Supplemental material (code, reused)
github.c...qBasichttps://github.com/Hughes-Genome-Group/NGseqBasic Supplemental material (code, reused)
github.com/open2c/coolpuppyhttps://github.com/open2c/coolpuppy Supplemental material (code, reused)
github.com/XiaoTaoWang/EagleChttps://github.com/XiaoTaoWang/EagleC Supplemental material (code, reused)
github.c...Finderhttps://github.com/XiaoTaoWang/NeoLoopFinder Supplemental material (code, reused)
pypi.org/project/runHiC/https://pypi.org/project/runHiC/ Supplemental material (code, reused)
goeseek.gwdguser.de/studies/345https://goeseek.gwdguser.de/studies/345 Supplemental material (goeseek study)
ars.els-...2.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S2211124726007278-mmc2.xlsx Supplemental material (table)
ars.els-...3.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S2211124726007278-mmc3.xlsx Supplemental material (table)
ars.els-...4.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S2211124726007278-mmc4.xlsx Supplemental material (table)
ars.els-...5.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S2211124726007278-mmc5.xlsx Supplemental material (table)
ars.els-...6.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S2211124726007278-mmc6.xlsx Supplemental material (table)
ars.els-...7.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S2211124726007278-mmc7.xlsx Supplemental material (table)
ars.els-...8.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S2211124726007278-mmc8.xlsx Supplemental material (table)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0004 |
|
primary |
HMGB2 |
AB_1140885 |
Anti-HMGB2 antibody |
| primary-0269 |
 |
primary |
PCNA |
AB_628110 |
Mouse monoclonal anti-PCNA (clone PC10) |
| primary-0423 |
|
primary |
HSPA8 |
AB_627761 |
HSPA8/HSC70 Antibody (B-6) |
| secondary-0008 |
|
secondary |
|
AB_2630356 |
Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) |
| secondary-0415 |
 |
secondary |
|
AB_955447 |
Goat Anti-Rabbit IgG H&L (HRP) |
| secondary-0425 |
|
secondary |
|
AB_2534016 |
Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 546 |
| secondary-0426 |
|
secondary |
|
AB_2534071 |
Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 546 |
| secondary-0427 |
|
secondary |
|
AB_955439 |
Goat Anti-Mouse IgG H&L (HRP) |
| secondary-0428 |
|
secondary |
|
AB_955021 |
Goat Anti-Rabbit IgG H&L (Cy3 ®) preadsorbed |
| secondary-0429 |
|
secondary |
|
AB_2576208 |
Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) |