| Property |
Value |
| Working Groups |
RG Stark, 
RG Urlaub |
| Subproject |
P04, P07 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
42399621 |
| DOI |
10.1038/s41467-026-75109-2 |
| Publication Year |
2026 |
| Title |
Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase |
| Journal |
Nature Communications |
| ISSN |
2041-1723 |
| eISSN |
2041-1723 |
| URL |
https://doi.org/10.1038/s41467-026-75109-2 |
| Issue |
1 |
| Volume |
17 |
| Journal Abbreviation |
Nat Commun |
| Authors |
Zhang Z, Kumar V, Panta S, Zhong J, Dybkov O, Dong H, Kastner B, Urlaub H, Stark H, Lührmann R |
| First Author |
Zhang Z |
| Last Author |
Lührmann R |
External Resources
nature.c...-2.pdfhttps://www.nature.com/articles/s41467-026-75109-2.pdf Article fulltext
EMD-53554https://www.ebi.ac.uk/pdbe/emdb/EMD-53554 EMBL-EBI EMDB identifier (EMD-53554)
EMD-53843https://www.ebi.ac.uk/pdbe/emdb/EMD-53843 EMBL-EBI EMDB identifier (EMD-53843)
gro-2/178048https://publications.goettingen-research-online.de/handle/gro-2/178048 GRO.publications identifier
ma-9luyyhttps://modelarchive.org/doi/10.5452/ma-9luyy ModelArchive identifier (ma-9luyy)
ma-ire8ehttps://modelarchive.org/doi/10.5452/ma-ire8e ModelArchive identifier (ma-ire8e)
ma-m2b6qhttps://modelarchive.org/doi/10.5452/ma-m2b6q ModelArchive identifier (ma-m2b6q)
ma-sd0aehttps://modelarchive.org/doi/10.5452/ma-sd0ae ModelArchive identifier (ma-sd0ae)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
0000-0003-2906-9346https://orcid.org/0000-0003-2906-9346 ORCID identifier (Zhenwei Zhang)
0000-0001-6642-8876https://orcid.org/0000-0001-6642-8876 ORCID identifier (Vinay Kumar)
0009-0006-9742-3692https://orcid.org/0009-0006-9742-3692 ORCID identifier (Sumeru Panta)
0000-0001-6005-7242https://orcid.org/0000-0001-6005-7242 ORCID identifier (Olexandr Dybkov)
0000-0002-5022-3494https://orcid.org/0000-0002-5022-3494 ORCID identifier (Haohao Dong)
0000-0002-6051-0198https://orcid.org/0000-0002-6051-0198 ORCID identifier (Berthold Kastner)
0000-0003-1837-5233https://orcid.org/0000-0003-1837-5233 ORCID identifier (Henning Urlaub)
0000-0002-6161-1118https://orcid.org/0000-0002-6161-1118 ORCID identifier (Holger Stark)
0000-0003-3253-7518https://orcid.org/0000-0003-3253-7518 ORCID identifier (Reinhard Lührmann)
5/58https://rdp.sfb1565.uni-goettingen.de/archive/5/58 Research Data Archive (supplemental material)
9R8Vhttps://www.rcsb.org/structure/9R8V RCSB PDB Identifier (DOI:10.2210/pdb9R8V/pdb)
6FF7https://www.rcsb.org/structure/6FF7 RCSB PDB Identifier (DOI:10.2210/pdb6FF7/pdb, reused)
7ABGhttps://www.rcsb.org/structure/7ABG RCSB PDB Identifier (DOI:10.2210/pdb7ABG/pdb, reused)
7ABIhttps://www.rcsb.org/structure/7ABI RCSB PDB Identifier (DOI:10.2210/pdb7ABI/pdb, reused)
8QO9https://www.rcsb.org/structure/8QO9 RCSB PDB Identifier (DOI:10.2210/pdb8QO9/pdb, reused)
8RO1https://www.rcsb.org/structure/8RO1 RCSB PDB Identifier (DOI:10.2210/pdb8RO1/pdb, reused)
011ashp19https://ror.org/011ashp19 ROR identifier (011ashp19, Sichuan University)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
007mrxy13https://ror.org/007mrxy13 ROR identifier (007mrxy13, West China Hospital of Sichuan University)
CVCL_0058https://scicrunch.org/resolver/CVCL_0058 SciCrunch identifier (RRID:CVCL_0058, HeLa S3)
SCR_025454https://scicrunch.org/resolver/SCR_025454 SciCrunch identifier (RRID:SCR_025454, AlphaFold)
SCR_014222https://scicrunch.org/resolver/SCR_014222 SciCrunch identifier (RRID:SCR_014222, Coot)
SCR_018392https://scicrunch.org/resolver/SCR_018392 SciCrunch identifier (RRID:SCR_018392, crYOLO)
SCR_016500https://scicrunch.org/resolver/SCR_016500 SciCrunch identifier (RRID:SCR_016500, GCTF)
SCR_014485https://scicrunch.org/resolver/SCR_014485 SciCrunch identifier (RRID:SCR_014485, MaxQuant)
SCR_016499https://scicrunch.org/resolver/SCR_016499 SciCrunch identifier (RRID:SCR_016499, MotionCor2)
SCR_022841https://scicrunch.org/resolver/SCR_022841 SciCrunch identifier (RRID:SCR_022841, PEAKS Studio)
SCR_014224https://scicrunch.org/resolver/SCR_014224 SciCrunch identifier (RRID:SCR_014224, Phenix)
SCR_016274https://scicrunch.org/resolver/SCR_016274 SciCrunch identifier (RRID:SCR_016274, RELION)
SCR_022215https://scicrunch.org/resolver/SCR_022215 SciCrunch identifier (RRID:SCR_022215, Thermo Exploris 480 nanoLC/MS system)
SCR_014593https://scicrunch.org/resolver/SCR_014593 SciCrunch identifier (RRID:SCR_014593, Thermo Xcalibur)
SCR_004097https://scicrunch.org/resolver/SCR_004097 SciCrunch identifier (RRID:SCR_004097, UCSF Chimera)
SCR_015872https://scicrunch.org/resolver/SCR_015872 SciCrunch identifier (RRID:SCR_015872, UCSF ChimeraX)
SCR_002380https://scicrunch.org/resolver/SCR_002380 SciCrunch identifier (RRID:SCR_002380, UniProt)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM1_ESM.pdf Supplemental material
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM2_ESM.pdf Supplemental material
goeseek.gwdguser.de/studies/293https://goeseek.gwdguser.de/studies/293 Supplemental material (goeseek study)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM12_ESM.pdf Supplemental material (peer review)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM11_ESM.pdf Supplemental material (reporting summary)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM13_ESM.pdf Supplemental material (source data)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM3_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM4_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM5_ESM.xlsx Supplemental material (table)
static-c...SM.mp4https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM6_ESM.mp4 Supplemental material (video)
static-c...SM.mp4https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM7_ESM.mp4 Supplemental material (video)
static-c...SM.mp4https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM8_ESM.mp4 Supplemental material (video)
static-c...SM.mp4https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM9_ESM.mp4 Supplemental material (video)
static-c...SM.mp4https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-75109-2/MediaObjects/41467_2026_75109_MOESM10_ESM.mp4 Supplemental material (video)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0422 |
|
primary |
SF3B1 |
AB_2880946 |
SF3B1 Polyclonal antibody |