| Property |
Value |
| Working Groups |
RG Bohnsack K.E., 
RG Bohnsack M.T., 
RG Höbartner, 
RG Stark, 
RG Urlaub |
| Subproject |
P04, P07, P12, P18 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
42031737 |
| DOI |
10.1038/s41467-026-72355-2 |
| Publication Year |
2026 |
| Title |
2′-O-methylation-dependent installation of N2-methylguanosine in the U6 internal stem loop facilitates efficient spliceosome assembly |
| Journal |
Nature Communications |
| ISSN |
2041-1723 |
| eISSN |
2041-1723 |
| URL |
https://www.nature.com/articles/s41467-026-72355-2 |
| Journal Abbreviation |
Nat Commun |
| Authors |
Kleiber N, Petrosyan J, Greve M, Thomé CC, Dybkov O, Tay LLE, Welp LM, Hackert P, Touboul D, Stark H, Bohnsack MT, Urlaub H, Herzel L, Graille M, Höbartner C, Bohnsack KE |
| First Author |
Kleiber N |
| Last Author |
Bohnsack KE |
External Resources
nature.c...-2.pdfhttps://www.nature.com/articles/s41467-026-72355-2.pdf Article fulltext
2/165040https://publications.goettingen-research-online.de/handle/2/165040 GRO.publications identifier
GSE270753https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE270753 NCBI GEO Dataset (GSE270753)
GSE270752https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE270752 NCBI GEO Dataset (GSE270752)
GSE303357https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303357 NCBI GEO Dataset (GSE303357)
0000-0003-0844-7547https://orcid.org/0000-0003-0844-7547 ORCID identifier (Nicole Kleiber)
0000-0001-6005-7242https://orcid.org/0000-0001-6005-7242 ORCID identifier (Olexandr Dybkov)
0009-0006-6703-7205https://orcid.org/0009-0006-6703-7205 ORCID identifier (Chairini Cássia Thomé)
0000-0003-0846-5200https://orcid.org/0000-0003-0846-5200 ORCID identifier (Luisa M. Welp)
0000-0002-6161-1118https://orcid.org/0000-0002-6161-1118 ORCID identifier (Holger Stark)
0000-0001-7063-5456https://orcid.org/0000-0001-7063-5456 ORCID identifier (Markus T. Bohnsack)
0000-0003-1837-5233https://orcid.org/0000-0003-1837-5233 ORCID identifier (Henning Urlaub)
0000-0002-4548-2299https://orcid.org/0000-0002-4548-2299 ORCID identifier (Claudia Höbartner)
0000-0001-6035-4255https://orcid.org/0000-0001-6035-4255 ORCID identifier (Katherine Elizabeth Bohnsack)
PXD053510http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD053510 Pride proteome dataset (PXD053510)
PXD053619http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD053619 Pride proteome dataset (PXD053619)
5/56https://rdp.sfb1565.uni-goettingen.de/archive/5/56 Research Data Archive (supplemental material)
05hy3tk52https://ror.org/05hy3tk52 ROR identifier (05hy3tk52, École polytechnique)
046ak2485https://ror.org/046ak2485 ROR identifier (046ak2485, Freie Universität Berlin)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
00fbnyb24https://ror.org/00fbnyb24 ROR identifier (00fbnyb24, University of Würzburg)
SCR_004129https://scicrunch.org/resolver/SCR_004129 SciCrunch identifier (RRID:SCR_004129, Zenodo)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM1_ESM.pdf Supplemental material
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM2_ESM.pdf Supplemental material
goeseek.gwdguser.de/studies/285https://goeseek.gwdguser.de/studies/285 Supplemental material (goeseek study)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM17_ESM.pdf Supplemental material (peer review)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM16_ESM.pdf Supplemental material (reporting summary)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM18_ESM.xlsx Supplemental material (source data)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM3_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM4_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM5_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM6_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM7_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM8_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM9_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM10_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM11_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM12_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM13_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM14_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-026-72355-2/MediaObjects/41467_2026_72355_MOESM15_ESM.xlsx Supplemental material (table)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0018 |
|
primary |
TUBA4A |
AB_477583 |
Anti-α-Tubulin antibody |
| primary-0145 |
|
primary |
THUMPD2 |
AB_10964424 |
Anti-THUMPD2 antibody produced in rabbit |
| primary-0149 |
|
primary |
TRMT112 |
|
TRMT112 Antikörper (F-7) |
| primary-0150 |
|
primary |
MEPCE |
AB_2250635 |
MEPCE Polyklonaler Antikörper |
| primary-0151 |
|
primary |
LARP7 |
AB_2132693 |
LARP7 Polyklonaler Antikörper |
| primary-0300 |
|
primary |
UTP14A |
AB_2272800 |
UTP14A Polyclonal antibody |
| primary-0370 |
 |
primary |
FLAG |
AB_259529 |
ANTI-FLAG® M2 antibody, Mouse monoclonal |
| primary-0385 |
|
primary |
TUBA1B |
AB_2210206 |
Alpha Tubulin Polyclonal antibody |
| primary-0386 |
|
primary |
SART3 |
AB_999668 |
SART3/TIP110 Polyclonal Antibody |
| primary-0387 |
|
primary |
FBRL |
AB_10916877 |
Fibrillarin Antibody (G-8) |
| primary-0388 |
|
primary |
EFTUD2 |
AB_805780 |
Rabbit anti-EFTUD2/SNRP116 Antibody Affinity Purified |
| primary-0389 |
|
primary |
PRPF4 |
AB_2171027 |
PRPF4 Polyclonal antibody |
| primary-0390 |
|
primary |
PRPF3 |
AB_2170994 |
PRPF3 Polyclonal antibody |
| primary-0391 |
|
primary |
PRPF8 |
|
PRPF8 (F4D7U) Rabbit Monoclonal Antibody |
| secondary-0185 |
 |
secondary |
|
AB_621847 |
IRDye® 800CW Donkey anti-Mouse IgG Secondary Antibody |
| secondary-0186 |
|
secondary |
|
AB_621848 |
IRDye® 800CW Donkey anti-Rabbit IgG Secondary Antibody |
| secondary-0327 |
|
secondary |
|
AB_621842 |
IRDye® 800CW Goat anti-Mouse IgG Secondary Antibody |
| secondary-0361 |
|
secondary |
|
AB_2535792 |
Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0392 |
|
secondary |
|
AB_10706167 |
IRDye® 680LT Donkey anti-Rabbit IgG Secondary Antibody |
| secondary-0393 |
|
secondary |
|
AB_10715072 |
IRDye® 680LT Donkey anti-Mouse IgG Secondary Antibody |